July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Full-field Electroretinographic Changes Among Uveitis Patients with Persistent Fluorescein Angiographic Retinal Vascular Leakage
Author Affiliations & Notes
  • Benjamin Chaon
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States
  • Ian Thompson
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States
  • Sapna Gangaputra
    Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, United States
  • Shilpa Kodati
    Department of Ophthalmology, Baylor University College of Medicine, Houston, Texas, United States
  • Chinwe Okeagu
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States
  • Hatice Nida Sen
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States
  • Footnotes
    Commercial Relationships   Benjamin Chaon, None; Ian Thompson, None; Sapna Gangaputra, None; Shilpa Kodati, None; Chinwe Okeagu, None; Hatice Sen, None
  • Footnotes
    Support  National Eye Institute Intramural Research Program
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4212. doi:
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      Benjamin Chaon, Ian Thompson, Sapna Gangaputra, Shilpa Kodati, Chinwe Okeagu, Hatice Nida Sen; Full-field Electroretinographic Changes Among Uveitis Patients with Persistent Fluorescein Angiographic Retinal Vascular Leakage. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4212.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The functional consequences of long-term, persistent vascular leakage in patients with uveitis remain unclear. To understand the effects of this leakage on photoreceptor and retinal function, we evaluated scotopic and photopic full-field ERG (ffERG) responses in uveitis patients with persistent angiographic vascular leakage.

Methods : Participants were recruited under an IRB-approved protocol (NCT02656381). 16 patients with persistent angiographic leakage were selected for inclusion in this study. Subjects met the following inclusion criteria: (1) Diagnosis of intermediate, posterior, or panuveitis (patients with a diagnosis of Birdshot chorioretinopathy were excluded); (2) Three or more quadrants of retinal vascular leakage on ultra-wide field fluorescein angiography in at least one eye; (3) No history of prior retinal laser photocoagulation; (4) Persistent angiographic leakage on at least two subsequent angiograms; and (5) No history of retinal degeneration or dystrophy. Participants underwent ffERG according to ISCEV standard protocol. Scotopic and photopic a-wave and b-wave amplitudes, oscillatory potentials, and implicit times were measured in all patients.

Results : 29 eyes of 16 patients with persistent angiographic vascular leakage were included. Participants ranged in age from 20-74 with a median age of 39.5 years. Median visual acuity measured 0.00 logMAR (20/20 Snellen equivalent). Median duration of angiographic leakage was 14.5 months (range 1 – 76 mo.). 21 of 29 (72.4%) eyes from 13 of 16 patients displayed at least 2 abnormal ffERG values. A prolonged photopic 30-hertz flicker implicit time was observed in 22 of 29 eyes (75.9%). 18 eyes (62.1%) had a decreased scotopic a-wave amplitude (0 db flash). 18 eyes (62.1%) had a decreased scotopic b-wave amplitude (0 db flash). 13 eyes (44.8%) had decreased light adapted cone b-wave amplitude, and 13 eyes (44.8%) had a prolonged light adapted b-wave implicit time. Uveitis patients with persistent angiographic leakage had a median of 5.0 abnormal ffERG values per eye.

Conclusions : Uveitis patients with persistent angiographic vascular leakage show evidence of photoreceptor dysfunction on ffERG testing indicating subclinical compromise of retinal function. ffERG may be a useful tool in monitoring patients and may have a potential to aid in treatment decisions.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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