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Yong-Sok Ji, Jae Yong Jang, Kyung Chul Yoon, Sang Woo Park; Feasibility of using magnetic nanoparticle-bioadhesive compound to repair experimental retinal detachment. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4228. doi: https://doi.org/.
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To investigate the effect of using magnetic nanoparticle-bioadhesive compound for treating experimental rhegmatogenous retinal detachment.
Magnetic nanoparticle-bioadhesive compound was developed with magnetic nanoparticle of the size between 100 and 200 nm and commercially available fibrin sealant (Evicel®; Ethicon, Bridgewater, NJ, Tesseel®; Baxter Healthcare, Deerfield, IL). In an in vitro study, retinal detachment with a peripheral tear was created in porcine eyecups after vitreous gel removal. After applying the newly developed magnetic scleral depressor outside the scleral wall, magnetic sealant was applied to cover the tear. Retinal adhesion strength was tested by forcefully squirting balanced salt solution (BSS) through a 20-gauge needle onto the retinal tear. In an in vivo study, magnetic sealant was injected into the vitreous cavity of rabbit eye. Ophthalmologic examinations were performed and bilateral ERGs were recorded before and 2 weeks after injection to evaluate its toxicity.
In the fluid-filled container, magnetic glue was effectively attracted by the externally applied magnet. With the porcine eyecup, magnetic sealant was attracted by the magnetic depressor and well attached to the retinal surface. A forceful squirt of BSS onto the retinal tear covered with magnetic sealant did not detach the retina, however, the retinal tear without sealant detached immediately. No inflammatory reaction was observed in the eyes throughout 2 weeks of follow-up. The ERGs recorded before and after injection showed typical patterns.
Magnetic nanoparticle-bioadhesive compound was attracted to the exact site of retinal tear by externally applied magnetic scleral depressor. The magnetic sealant appeared to effectively seal retinal breaks.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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