Real-World Evidence Based on the Results of a Multicenter Study in Japan of Surgical Procedures for Young Japanese Patients with Rhegmatogenous Retinal Detachment

Abstract

Purpose : To establish real-world evidence for younger Japanese Rhegmatogenous Retinal Detachment (RRD) patients by examining retrospectively baseline characteristics, surgical procedures, and clinical outcomes in the Japan Clinical Retina Study Group (J-CREST).

Methods : This study was a multicenter (J-CREST) retrospective study. Between April 2013 and August 2016, a total of 565 young patients (385 males, 180 females; mean age: 33.0 ± 11.8 years) who had been diagnosed as RRD and underwent surgical procedures in various hospitals were analyzed on the basis of data from medical records (the observation period after surgery was more than 6 months for all subjects analyzed).

Results : The selected surgeries were scleral buckling (SB) for 295 eyes (49.4%), and pars plana vitrectomy (PPV) for 265 eyes (44.4%). In the eyes with SB and PPV, the rate of macula-on cases was 32.5% and 21.1%, respectively. For the two surgical procedures, there were no significant differences in the first anatomical success rate (SB=92.2%, PPV=94.0%) and there were improvements in visual acuity. The incidence of cataracts within one year of PPV, however, was as high as 4.17% (0.34% in the SB).

Conclusions : In this study, SB and PPV were chosen in equal ratios for younger RRD patients. The results indicated that SB and PPV were equivalent for young Japanese RRD patients as to first anatomical success rate. It is necessary, however, to pay attention to the incidence of cataracts after PPV.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.