July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Effects of orbital external beam radiation therapy on the eye
Author Affiliations & Notes
  • Camila M Endo
    Santa Casa of São Saulo, Sao Paulo, SP, Brazil
  • Ivana Kusabara
    Santa Casa of São Saulo, Sao Paulo, SP, Brazil
  • Jose Vital Filho
    Santa Casa of São Saulo, Sao Paulo, SP, Brazil
  • Footnotes
    Commercial Relationships   Camila M Endo, None; Ivana Kusabara, None; Jose Vital Filho, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4306. doi:https://doi.org/
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      Camila M Endo, Ivana Kusabara, Jose Vital Filho; Effects of orbital external beam radiation therapy on the eye. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4306. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : Radiotherapy is widely used for the treatment of orbital tumors and inflammatory processes. Over the years, knowledge about the effects of radiation, its techniques and dosage, have contributed to its establishment as an important therapy of eye diseases. The purpose of this study is to describe the ocular findings in patients submitted to orbital external beam radiation therapy (EBRT).

Methods : Thirty-two patients (10 males, age of 51.6 years old) submitted to orbital EBRT of the Orbit outpatient clinic of the Department of Ophthalmology of Santa Casa of São Paulo during 2007 and 2017 were analyzed in this study. The following data were collected: diagnosis, total dose and fractionation of radiation, ocular complication, the interval between radiotherapy and diagnosis of ocular complication, and complementary treatment, if present.

Results : Among the diagnosis, 4 (12.5%) had idiopathic inflammatory orbital disease, 27 (84.5%) had orbital tumors, 17 of which were lymphomas, and 1 case had Rosai Dorfman’s Disease. Five (15.7%) patients received doses up to 20 Gys, 17 (53.1%) were submitted to doses between 21 Gys and 44 Gys, 9 (28.1%) received doses between 45 Gys and 60 Gys, and only 1 (3.1%) patient received dose higher than 60 Gys. Of the total of patients, 19 (59.3%) developed ocular complications. Among the 25 ocular complications characterized in the study, 21 (84%) involved anterior segment and 2 (8%) involved the posterior segment, in addition to 2 (8%) cases of facial bone hypoplasia.

Conclusions : More than half of the patients developed some ocular complication until the moment of the study. Most of the complications involved the anterior segment and cataract was the most frequent. Radiation retinopathy and facial bone hypoplasia occurred in patients submitted to higher doses of radiotherapy. None of the evaluated cases developed neuropathy by radiation.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.


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