July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Assessment of immune checkpoint inhibitors expression in Uveal Melanoma
Author Affiliations & Notes
  • Chen Liang
    Ophthalmology, Si Chuan University, Cheng Du, China
  • Lin QIAO Tang
    Ophthalmology, Si Chuan University, Cheng Du, China
  • Jun Jun Zhang
    Ophthalmology, Si Chuan University, Cheng Du, China
  • Footnotes
    Commercial Relationships   Chen Liang, None; Lin QIAO Tang, None; Jun Jun Zhang, None
  • Footnotes
    Support  NSFC H1205
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4308. doi:https://doi.org/
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      Chen Liang, Lin QIAO Tang, Jun Jun Zhang; Assessment of immune checkpoint inhibitors expression in Uveal Melanoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4308. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The aim of this study was to analyze the expression of immune checkpoint inhibitors in uveal melanoma and its prognostic significance<embed height="0" id="xunlei_com_thunder_helper_plugin_d462f475-c18e-46be-bd10-327458d045bd" type="application/thunder_download_plugin" width="0" />

Methods : 23 enucleated eyes from UM patients with clinical information were analyzed. Immunostaining was performed with antibodies including: PDL1, CTLA4, IDO1 and TIM3. Retina, breast cancer and tonsil were used as positive control. Immunostaining results were evaluated by 2 pathologists. Univariate analysis was used to evaluate the checkpoint inhibitors association with metastasis free survival (MFS).<embed height="0" id="xunlei_com_thunder_helper_plugin_d462f475-c18e-46be-bd10-327458d045bd" type="application/thunder_download_plugin" width="0" />

Results : PDL-1 was positive in 54.2% of the cases. PD-L1 expression was associated with a longer MFS (p<0.05). Both IDO1 and TIM3 were expressed in all cases and the most of positive cells were located at the peripheral of tumor lesions. However, we didn’t detect any CTLA4 expression in uveal melanoma.<embed height="0" id="xunlei_com_thunder_helper_plugin_d462f475-c18e-46be-bd10-327458d045bd" type="application/thunder_download_plugin" width="0" />

Conclusions : PDL-1, IDO1, TIM3, but not CTLA4 were expressed in UM. The expression of PDL-1 in UM is associated with longer MFS. IDO1 and TIM3 were constantly expressed in UM<embed height="0" id="xunlei_com_thunder_helper_plugin_d462f475-c18e-46be-bd10-327458d045bd" type="application/thunder_download_plugin" width="0" />

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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