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Jin Ah Lee, Hunjae Won, Sungwoo Maeng, Hyuntae Kim, Hyung Joon Cha, Hungwon Tchah, Myoung Joon Kim; Watertight cataract incision closure using Mussel protein-based bioadhesive. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4341.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate whether applying a Mussel protein-based bioadhesive to a clear corneal cataract incision can create a watertight seal.
An infusion cannula was placed to maintain constant eye pressure. Clear corneal cataract incisions were simulated in 9 porcine eyes. In 3 eyes, fibrin tissue adhesive was applied to the incision. In 3 eyes, Mussel protein-based bioadhesive was applied to the wound site. The other 3 eyes were controls with no adhesive. Each eye was tested under low pressure conditions to detect fluid ingress of Lissamine green on the eye’s surface. As the height of the infusion bottle was gradually increased, the height at which the fluid leakage was observed was recorded.
In the eyes without adhesive, we could observe the incision distortion and ingress of lissamine green, at 9cm height (low pressure). In the eyes with fibrin tissue adhesive and Mussel protein based bioadhesive, there was no engress of fluid with incision distortion and no ingress, under low pressure conditions. In fibrin tissue adhesive cases, At the 76.33 cm of height, we could observe the leakage at the incision site. In Mussel protein-based bioadhesive cases, there was a leak at the 116 cm of height.
Applying a Mussel protein-based bioadhesive to cataract incision site could make a watertight seal that can withstand high pressures.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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