July 2018
Volume 59, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2018
Watertight cataract incision closure using Mussel protein-based bioadhesive
Author Affiliations & Notes
  • Jin Ah Lee
    ophthalmology, Asan medical center, Seoul, Korea (the Republic of)
  • Hunjae Won
    Namsan community health care branch, Seoul, Korea (the Republic of)
  • Sungwoo Maeng
    Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Korea (the Republic of)
  • Hyuntae Kim
    ophthalmology, Asan medical center, Seoul, Korea (the Republic of)
  • Hyung Joon Cha
    Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, Korea (the Republic of)
  • Hungwon Tchah
    ophthalmology, Asan medical center, Seoul, Korea (the Republic of)
  • Myoung Joon Kim
    ophthalmology, Asan medical center, Seoul, Korea (the Republic of)
  • Footnotes
    Commercial Relationships   Jin Ah Lee, Partner – Nature Gluetech (C); Hunjae Won, None; Sungwoo Maeng, Partner – Nature Gluetech (C); Hyuntae Kim, None; Hyung Joon Cha, Nature Gluetech (I); Hungwon Tchah, None; Myoung Joon Kim, Partner – Nature Gluetech (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4341. doi:
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    • Get Citation

      Jin Ah Lee, Hunjae Won, Sungwoo Maeng, Hyuntae Kim, Hyung Joon Cha, Hungwon Tchah, Myoung Joon Kim; Watertight cataract incision closure using Mussel protein-based bioadhesive. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4341.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate whether applying a Mussel protein-based bioadhesive to a clear corneal cataract incision can create a watertight seal.

Methods : An infusion cannula was placed to maintain constant eye pressure. Clear corneal cataract incisions were simulated in 9 porcine eyes. In 3 eyes, fibrin tissue adhesive was applied to the incision. In 3 eyes, Mussel protein-based bioadhesive was applied to the wound site. The other 3 eyes were controls with no adhesive. Each eye was tested under low pressure conditions to detect fluid ingress of Lissamine green on the eye’s surface. As the height of the infusion bottle was gradually increased, the height at which the fluid leakage was observed was recorded.

Results : In the eyes without adhesive, we could observe the incision distortion and ingress of lissamine green, at 9cm height (low pressure). In the eyes with fibrin tissue adhesive and Mussel protein based bioadhesive, there was no engress of fluid with incision distortion and no ingress, under low pressure conditions. In fibrin tissue adhesive cases, At the 76.33 cm of height, we could observe the leakage at the incision site. In Mussel protein-based bioadhesive cases, there was a leak at the 116 cm of height.

Conclusions : Applying a Mussel protein-based bioadhesive to cataract incision site could make a watertight seal that can withstand high pressures.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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