July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Acute hydrops of recurrent keratoconus after penetrating keratoplasty may occur in a different way from that of naïve keratoconus
Author Affiliations & Notes
  • Asahi Fujita
    ophthalmology, University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Junko Yoshida
    ophthalmology, University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Tetsuya Toyono
    ophthalmology, University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Rika Shirakawa
    ophthalmology, University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Takashi Miyai
    ophthalmology, University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Tomohiko Usui
    ophthalmology, University of Tokyo, Bunkyo-ku, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Asahi Fujita, None; Junko Yoshida, None; Tetsuya Toyono, None; Rika Shirakawa, None; Takashi Miyai, None; Tomohiko Usui, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4378. doi:
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      Asahi Fujita, Junko Yoshida, Tetsuya Toyono, Rika Shirakawa, Takashi Miyai, Tomohiko Usui; Acute hydrops of recurrent keratoconus after penetrating keratoplasty may occur in a different way from that of naïve keratoconus. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4378.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Keratoconus recurrence sometimes occurs decades after successful PK. Acute hydrops after keratoconus recurrence is a very rare complication and the details has not been adequately investigated so far. This study is aimed to find out clinical characteristics of acute hydrops in eyes with recurrent KC by comparing those with naïve KC.

Methods : We performed a retrospective medical record review of patients at the University of Tokyo Hospital to compare the features of acute hydrops of recurrent KC and those of naïve KC. Four eyes of 4 patients with acute hydrops after PK (PK group) and 29 acute hydrops eyes of 27 patients with naïve KC (control group) were included in this study. The clinical courses, corneal topography and anterior segment optical coherence tomography (AS-OCT) data were evaluated.

Results : The mean age of PK group was 54.8±5.7 years old (4 males), while in control group was 28.4±9.9 years old (22 males and 5 females). In PK group, acute hydrops occurred 22.3±4.0 years after PK. We had AS-OCT data at the time of acute hydrops’ onset for all eyes in PK group and 10 eyes in control group. Descemet’s membrane’s breaks were observed around the host-graft junction in all eyes of PK group, while it was observed at paracentral area in all eyes in control group. Descemet’s membrane’s detachment was observed in 3 eyes of PK group (75%) and 3 eyes of control group (30%). PK was performed on 3 eyes of PK group (75%) and 8 eyes of control group (28%). The mean changes of steepest keratometry value before the acute hydrops onset were +0.72±0.44 Diopter (D)/year in PK group and -0.78±2.39 D/year in control group.

Conclusions : KC progresses decades after PK, which may lead to acute hydrops in some cases. The clinical findings and characteristics of acute hydrops after KC recurrence showed different Descemet’s rupture location and topographic changes over time from those of naïve KC.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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