July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
The influence of visual pathway integrity on primary and higher order visual dysfunction in synucleinopathies
Author Affiliations & Notes
  • Ane Murueta-Goyena Larranaga
    Neurodegenerative Diseases Group, BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
  • Marta Galdos
    Ophthalmology, Cruces University Hospital, Barakaldo, Bizkaia, Spain
  • Olaia Lucas
    Psychology, Deusto University, Bilbao, Bizkaia, Spain
  • Begoña Arana
    Ophthalmology, Cruces University Hospital, Barakaldo, Bizkaia, Spain
  • Marian Acera
    Neurodegenerative Diseases Group, BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
  • Rocio Del Pino
    Neurodegenerative Diseases Group, BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
  • Naroa Ibarretxe
    Psychology, Deusto University, Bilbao, Bizkaia, Spain
  • Ibai Diez
    Computational Neuroimaging Group, BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
  • Alberto Cabrera
    Neuroradiology, Osatek, Galdakao, Bizkaia, Spain
  • Juan Carlos Gómez-Esteban
    Neurodegenerative Diseases Group, BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
  • Inigo Gabilondo
    Neurodegenerative Diseases Group, BioCruces Health Research Institute, Barakaldo, Bizkaia, Spain
  • Footnotes
    Commercial Relationships   Ane Murueta-Goyena Larranaga, None; Marta Galdos, None; Olaia Lucas, None; Begoña Arana, None; Marian Acera, None; Rocio Del Pino, None; Naroa Ibarretxe, None; Ibai Diez, None; Alberto Cabrera, None; Juan Carlos Gómez-Esteban, None; Inigo Gabilondo, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4648. doi:
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      Ane Murueta-Goyena Larranaga, Marta Galdos, Olaia Lucas, Begoña Arana, Marian Acera, Rocio Del Pino, Naroa Ibarretxe, Ibai Diez, Alberto Cabrera, Juan Carlos Gómez-Esteban, Inigo Gabilondo; The influence of visual pathway integrity on primary and higher order visual dysfunction in synucleinopathies. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4648.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To identify visual pathway neuroimaging variables (OCT and brain MRI) associated to primary and higher order visual dysfunction in idiopathic Parkinson’s disease (iPD), Lewy Body Dementia (LBD) and E46K-SNCA mutation carriers (E46K-SNCA).

Methods : Cross-sectional study of n=63 patients with synucleinopathies (n=50 iPD, n=8 LBD and n=5 E46K-SNCA) and n=22 age/sex comparable healthy controls (HC). Measures: 1) Retinal OCT (Spectralis): 3 mm ring bilateral average thickness of macula and its layers; 2) Brain MRI (3 Tesla): regional brain thickness and Voxel Based Morphometry (Freesurfer/FSL), visual and frontal cortex spectroscopy (NAA levels) (Tarquin), optic radiations DTI indexes (FA) (FSL) and internal and external connectivity of medial visual component (MVC) in rs-fMRI; 3) Higher order visual function (HOVF) tests with composites for attention, processing speed, construction and memory; 4) Primary visual function (PVF): binocular best-corrected high and low contrast visual acuity (HCVA and LCVA), Pelli-Robson contrast sensitivity (CS) and color vision (Lanthony D-15 Color Test); 5) PD clinical features (UPDRS, disease duration). Statistical analysis: Student's T-test differences between groups, Pearson correlations and linear regressions (SPSS v. 21).

Results : Compared to HC, patients with synucleinopathies had statistically significant (p〈0.05) poorer results in all PVF and HOVF tests/composites, atrophy of ganglion cell-inner plexiform layer complex (GCIPL), inner nuclear layer (INL), lower NAA levels in visual (not in frontal) cortex, regional bilateral atrophy of inferior, middle and superior temporal, fusiform, lingual and middle occipital gyri and left calcarine gyrus. In patients, and not in HC, higher atrophy of inner retina (GCIPL and INL), calcarine cortex, fusiform and lingual gyri and lower rs-fMRI connectivity of MVC with precuneus were significantly associated to poorer performance in HCVA, LCVA and CS, while atrophy of IPL and INL and middle temporal gyrus, and lower rs-fMRI connectivity of MVC with cuneus were significantly associated with poorer performance in HOVF composites.

Conclusions : Primary and higher order visual abnormalities in synucleinopathies are specifically associated to the damage of the retina and visual regions of the brain, supporting the use of visual pathway analysis as a potential biomarker for neurodegeneration in synucleinopathies.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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