Superiority of ultra-wide field retinal imaging on detection of fundus abnormalities in the general medical checkup (human dock)

Abstract

Purpose : Non-mydriatic fundus photography has been commonly used in the general annual medical checkup (human dock) in Japan. The purpose of this study is to compare ultra-wide field retinal imaging and non-mydriatic fundus photography in the general annual medical checkup. And we also evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF).

Methods : This is a prospective observation study. 10742 eyes of 5371 subjects were taken fundus photographs by non-mydriatic retinal camera (Canon CR-DG10) between April 2014 and March 2015 (Group 1). Ultra-wide field retinal imaging (Optos^® Daytona) was used to take fundus photographs for 10602 eyes of 5301 people between April 2015 and March 2016 (Group 2). Both of the ratio of defective image at posterior pole and the ratio of detection of various diseases were reviewed. In Group 2, the FAF image were also assessed and abnormal peripheral FAF pattern was evaluated.

Results : Retinal detachment (8 eyes), peripheral retinal break (28 eyes) and peripheral retinal degeneration (45 eyes) were detected in the Group 2 although none of the peripheral lesions was detected in the Group 1. Diabetic retinopathy and macular degeneration were detected in 36 eyes and 47 eyes in the Group 1, 48 eyes and 66 eyes in the Group 2. Epiretinal membrane was detected in 118 eyes in the Group 1, 29 eyes in the Group 2. The defective image ratio in the Group 1 (107 eyes, 1.0%) was significantly higher than in the Group 2 (4 eyes, 0.04%).
In Group 2, peripheral increased autofluorescence was detected in 75 eyes (drusen 45 eyes and others 30 eyes) and peripheral decreased autofluorescence was detected in 78 eyes (retinal pigment epithelium degeneration 16eyes, retinal pigment epithelium atrophy 53 eyes and laser scar 9 eyes).

Conclusions : In general annual medical checkup, ultra-wide field retinal imaging is superior to non-mydriatic fundus photography for its detecting the peripheral retinal lesions and the peripheral age related autofluorescence changes.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.