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Nida Mumtaz Khan, Marko Dimiskovski, Weiye Li; Linking Anterior and Posterior Segment Biometry in High Myopia. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4734.
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© ARVO (1962-2015); The Authors (2016-present)
Pathological changes of both anterior and posterior segments in patients with high myopia have been well established. However, the quantitative relationship between the anterior and posterior biometric measurements has not been well studied.
30 eyes of 16 patients with high myopia (defined > - 6.50D) were included in this cross-sectional study. Postoperative patients, those with anterior or posterior segment disease, congenital abnormality, amblyopia/ strabismus, and/or the active use of contact lenses were excluded. The following single measurements were recorded: auto-refraction (AF) by Topcon KR 8000; central corneal thickness (CCT) by Accutome Pachpen; anterior chamber depth (ACD) and axial length (AL) by IOL master 500; parapapillary atrophy width (PPA), central sub-foveal thickness (CSFT), and subfoveal choroidal thickness (ChT) manually by Spectralis SD OCT. Two tailed t-tests were used to assess two group comparisons. Multi-group comparisons were analyzed with one-way ANOVA. P-values less than 0.05 were considered statistically significant.
A statistically significant correlation was found between auto-refraction (AF) and axial length (AL) (p = 0.0005). One-way ANOVA showed that AF or AL significantly correlated with CCT (p < 0.001), PPA (p < 0.001), CSFT (p < 0.001), and ChT (p < 0.001), respectively. Neither AF nor AL was associated with ACD (p = 0.98).
Eyes with increasingly high myopia manifest thinner corneas, longer axial lengths, thinner foveal thickness, thinner choroidal thickness and wider parapapillary atrophy. However, the progression of high myopia does not change anterior chamber depth. These findings indicate that pathological high myopia is a global degenerative disease that potentially impacts both anterior and posterior segment structure and function. The global biometric data in pathological high myopia may be useful as guidelines for pre- and post-refractive surgery monitoring.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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