July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Optical coherence tomography analysis of patients with untreated diabetic macular edema
Author Affiliations & Notes
  • Haiying Chen
    The Royal Melbourne Hospital, Melbourne, Victoria, Australia
  • Mei Hong Tan
    Department of Ophthalmology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia
  • Dustin Pomerleau
    Department of Ophthalmology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia
  • Elaine W Chong
    Department of Ophthalmology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Centre for Eye Research Australia, Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia
  • Lyndell L Lim
    Department of Ophthalmology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Centre for Eye Research Australia, Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia
  • Robert Charles Andrew Symons
    Department of Ophthalmology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia
    Department of Surgery, The University of Melbourne, Melbourne, Victoria, Australia
  • Footnotes
    Commercial Relationships   Haiying Chen, None; Mei Hong Tan, Bayer (F); Dustin Pomerleau, Novartis (F); Elaine Chong, None; Lyndell Lim, Abbvie (F), Allergan (F), Bayer (F); Robert Symons, CSL Pty. Ltd. (I), Novartis (F), Psivida (I)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4830. doi:
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    • Get Citation

      Haiying Chen, Mei Hong Tan, Dustin Pomerleau, Elaine W Chong, Lyndell L Lim, Robert Charles Andrew Symons; Optical coherence tomography analysis of patients with untreated diabetic macular edema. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4830.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the natural history of untreated diabetic macular edema (DME) over a six to twelve-month period;
To study the predictive values of medical and ophthalmic factors on the natural history of DME.

Methods : Macular optical coherence tomography (OCT) scans of patients with diabetes at a tertiary hospital were assessed. The first scan of an eye that demonstrated the presence of DME was compared with a subsequent scan six to twelve months following the initial scan. Medical and ophthalmic data of the patients/eyes were collected from medical records.

Results : In 97 eyes, there was no significant change from the baseline visual acuity 6/9 (inter-quartile range 6/6 – 6/12) or from the baseline median central subfield thickness (290 μm, inter-quartile range 270 μm – 312 μm) over a median duration of eight months. The numbers of eyes where the central subfield thickness (CSFT) had worsened, improved, or remained stable were 16 (16%), 6 (6%), and 74 (76%), respectively. Patients with hemoglobin A1c of greater than 8.5% were 5.7 times more likely to develop CSFT worsening (95% confidence interval 1.1 – 30.1, P = 0.038). Patients with shorter duration of diabetes or with greater baseline central subfield thicknesses were more likely to demonstrate reductions in CSFT.

Conclusions : The majority of eyes with diabetic macular edema identified on optical coherence tomography had stable central retinal thicknesses without treatment over a median duration of eight months. Hemoglobin A1c, duration of diabetes and central subfield thickness on optical coherence tomography may be useful for risk stratification.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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