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Kumiko Hirayama, Manabu Yamamoto, Takeya Kohno, Dirk Theissen-Kunde, Yoko Miura, Ralf Brinkmann, Kunihiko Shiraki; Predictive factors of selective retina therapy for diabetic macular edema. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4831. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the predictive factors of Selective Retina Therapy (SRT) for diabetic macular edema (DME).
This retrospective study included 19 eyes of 16 patients (9 males and 7 females), who were treated with SRT for DME at the department of Ophthalmology of Osaka City University Hospital, and observed at least 6 months after treatment. Mean age was 64 years old (range 46-75). Eleven of the 19 eyes (58%) had a treatment history other than SRT. SRT laser (527 nm, 1.7 µs, 100 Hz; Medical Laser Center Lübeck, Germany) was used for treatment. The changes of logMAR best corrected visual acuity (BCVA) and central macular thickness (CMT) in optical coherence tomography (OCT) were examined at baseline, 3-month follow-up, and 6-month follow-up. We defined the decrease of >15% of CMT compared to pretreatment as ‘improvement’. Association between the clinical characteristics at baseline and the incidence of “improvemnet” was analyzed.
The mean logMAR BCVA was 0.27±0.32, 0.21±0.23 and 0.27±0.31 at baseline, 3 months, and 6 months, respectively (P=0.09 at 3 months, 0.94 at 6 months; as compared with baseline). The mean CMT was 486±145 μm, 449±180 μm, 413±181 μm at baseline, 3 months, and 6 months, respectively (P=0.16 at 3 months, <0.05 at 6 months; as compared with baseline). The history of macular photocoagulation was significantly negatively associated with the incidence of “improvement” (P=0.02).
The CMT was significantly decreased at 6 months after SRT in DME. The history of macular photocoagulation may adversely affect the effect of SRT.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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