July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Posterior subtenon infusion of triamcinolone acetonide as adjunctive treatment to panretinal photocoagulation using pattern scan laser for severe diabetic retinopathy
Author Affiliations & Notes
  • Yutaka Yamada
    University of fukui, Yoshida, Fukui, Japan
  • Yoshihiro Takamura
    University of fukui, Yoshida, Fukui, Japan
  • takehiro matsumura
    University of fukui, Yoshida, Fukui, Japan
  • masakazu morioka
    University of fukui, Yoshida, Fukui, Japan
  • makoto gozawa
    University of fukui, Yoshida, Fukui, Japan
  • Masaru Inatani
    University of fukui, Yoshida, Fukui, Japan
  • Footnotes
    Commercial Relationships   Yutaka Yamada, None; Yoshihiro Takamura, None; takehiro matsumura, None; masakazu morioka, None; makoto gozawa, None; Masaru Inatani, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4852. doi:
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      Yutaka Yamada, Yoshihiro Takamura, takehiro matsumura, masakazu morioka, makoto gozawa, Masaru Inatani; Posterior subtenon infusion of triamcinolone acetonide as adjunctive treatment to panretinal photocoagulation using pattern scan laser for severe diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4852.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To estimate the effect of sub-Tenon’s capsule triamcinolone acetonide injection (STTA) combined with panretinal photocoagulation (PRP) using pattern scan laser (PSL) for high risk non-proliferative diabetic retinopathy (NPDR), in terms of the inflammation and the progression of diabetic macular edema (DME).

Methods : This retrospective study includes NPDR patients underwent PRP using PSL with (STTA+PSL group, n=24) or without pretreatment of STTA (PSL group, n=19). We measured anterior flare intensity (AFI) and central retinal thickness (CRT) at day of STTA (day 0), 1, 3, 7, 11 and 15 weeks.

Results : The CRT of the STTA+PSL group was significantly lower than that of the PSL group at 7 (p = 0.04), 11 (p = 0.01) and 15 weeks (p = 0.02). AFI levels in the STTA+PSL group were significantly lower than those in the PSL group at 11 (p = 0.007) and 15 weeks (p = 0.009). The significant improvement of CRT from baseline was noticed through the observational periods in STTA+PSL group, but not in the PSL group.

Conclusions : Pretreatment of STTA has the potential to not only prevent the worsening of DME, but also reduce the CRT and AFI of eyes with NPDR after PRP using PSL.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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