Abstract
Purpose :
To evaluate sleep and mood status in Chinese adult patients with dry eye disease and the association between sleep quality, mood disorders and ocular surface characteristics in dry eye patients (DED).
Methods :
One hundred and six consecutive patients with DED and 50 age- and sex-matched controls were enrolled. Lacrimal secretion, tear breakup time (TBUT) and corneal fluorescein staining score were evaluated. A self-scored grade of 0-10 for severity of discomfort was achieved. All subjects completed the Pittsburgh Sleep Quality Index (PSQI), the Patient Health Questionnaire (PHQ-9) and the General Anxiety Disorder Scale (GAD-7) questionnaires.
Results :
The total mean PSQI global score of DED patients was 7.88±0.37, significantly higher than the controls (5.15±0.73, p=0.014). DED patients showed more depressive than the control ones (5.22±0.48 vs 2.61±0.73, p=0.014). Lacrimal secretion was associated with sleep duration (adjusted-p=0.039). In addition, sleep quality was also associated with higher mood disorders scores, including depression (odds ratio [OR]: 1.29, 95% confidence interval [CI]: 1.10-1.53, adjusted-p=0.002) and anxiety (OR: 1.19, 95% CI: 1.04-1.37, adjusted-p=0.011).
Conclusions :
Patients with dry eye disease has a poorer sleep quality and mood status. The sleep quality of DED patients may be affected by their mood status, including depression and anxiety. Sleep duration may also has an association with lacrimal secretion. Intervention for sleep and mood disorders in DED patients may be needed to improve their quality of life.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.