July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Sleep and mood disorders in Chinese adult patients with dry eye
Author Affiliations & Notes
  • Yan Wang
    Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
  • Mengliang Wu
    Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
  • Jing Han
    Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
  • Tingting Shao
    Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China
  • Footnotes
    Commercial Relationships   Yan Wang, None; Mengliang Wu, None; Jing Han, None; Tingting Shao, None
  • Footnotes
    Support  This research was supported by the National Science Foundation for Young Scientists of China (No. 81100636)
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 4878. doi:
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      Yan Wang, Mengliang Wu, Jing Han, Tingting Shao; Sleep and mood disorders in Chinese adult patients with dry eye. Invest. Ophthalmol. Vis. Sci. 2018;59(9):4878.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To evaluate sleep and mood status in Chinese adult patients with dry eye disease and the association between sleep quality, mood disorders and ocular surface characteristics in dry eye patients (DED).

Methods : One hundred and six consecutive patients with DED and 50 age- and sex-matched controls were enrolled. Lacrimal secretion, tear breakup time (TBUT) and corneal fluorescein staining score were evaluated. A self-scored grade of 0-10 for severity of discomfort was achieved. All subjects completed the Pittsburgh Sleep Quality Index (PSQI), the Patient Health Questionnaire (PHQ-9) and the General Anxiety Disorder Scale (GAD-7) questionnaires.

Results : The total mean PSQI global score of DED patients was 7.88±0.37, significantly higher than the controls (5.15±0.73, p=0.014). DED patients showed more depressive than the control ones (5.22±0.48 vs 2.61±0.73, p=0.014). Lacrimal secretion was associated with sleep duration (adjusted-p=0.039). In addition, sleep quality was also associated with higher mood disorders scores, including depression (odds ratio [OR]: 1.29, 95% confidence interval [CI]: 1.10-1.53, adjusted-p=0.002) and anxiety (OR: 1.19, 95% CI: 1.04-1.37, adjusted-p=0.011).

Conclusions : Patients with dry eye disease has a poorer sleep quality and mood status. The sleep quality of DED patients may be affected by their mood status, including depression and anxiety. Sleep duration may also has an association with lacrimal secretion. Intervention for sleep and mood disorders in DED patients may be needed to improve their quality of life.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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