July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Blood flow rate of ophthalmic artery in patients with normal tension glaucoma and healthy controls
Author Affiliations & Notes
  • Martin Kristiansen
    Dept. of Clinical Science, Umeå University, Umeå, Sweden
  • Christina Lindén
    Dept. of Clinical Science, Umeå University, Umeå, Sweden
  • Sara Qvarlander
    Dept. of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, Sweden
  • Anders Wåhlin
    Dept. of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, Sweden
  • Khalid Ambarki
    Dept. of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, Sweden
  • Per Hallberg
    Dept. of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, Sweden
  • Anders Eklund
    Dept. of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, Sweden
  • Gauti Johannesson
    Dept. of Clinical Science, Umeå University, Umeå, Sweden
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5055. doi:
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      Martin Kristiansen, Christina Lindén, Sara Qvarlander, Anders Wåhlin, Khalid Ambarki, Per Hallberg, Anders Eklund, Gauti Johannesson; Blood flow rate of ophthalmic artery in patients with normal tension glaucoma and healthy controls. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5055.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To determine the blood flow rate of the ophthalmic artery (OA) in patients with Normal Tension Glaucoma (NTG) compared to age-matched healthy controls using phase-contrast magnetic resonance imaging (PCMRI).

Methods : Seventeen patients with treated NTG (11 female; mean age: 70±9 years) and 16 age-matched healthy controls (10 female; mean age: 71±9 years) underwent PCMRI using a 3-Tesla scanner as well as ophthalmological examinations including visual acuity, Goldmann Applanation Tonometry, Humphrey perimetry and fundoscopy. Ophthalmic blood flow was acquired using a 2D PCMRI sequence set to a spatial resolution of 0.35mm/pixel. Mean flow rate and cross-sectional area was calculated using Segment Software. The eye with the most severe glaucomatous damage classified by visual field index (VFI) was chosen for comparison. The primary outcome was blood flow rate of OA.

Results : The mean VFI was 41% ± 26 (mean±SD) for the worse NTG eyes. The intraocular pressure was 13.6±2.6 mmHg for NTG eyes and 13.8±2.1 mmHg for control eyes. The blood flow rate in the NTG group was 9.6±3.7 ml/min compared to 11.8±5.5 ml/min in the control group. The area was 1.7±0.3 mm2 and 2.0±0.6 mm2 respectively. No statistical significance was found between NTG and the control group regarding blood flow rate (p=0.07) or OA area (p=0.12).

Conclusions : Despite OA being an anastomosis between the intracranial and extracranial circulation, possibly generating an eye unrelated variability in blood flow, we found a trend level reduction of approximately 2 ml/min in NTG. The finding warrants blood flow rate analysis of smaller arteries specifically supplying the eye, e.g. the central retinal artery.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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