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Alice Chandra Verticchio Vercellin, Alon Harris, Brent A Siesky, David Camp, Aaditya Shah, Aditya Belamkar, Sunu Mathew, Thomas A Ciulla; Optic nerve head morphology at baseline is associated with changes in capillary blood flow in diabetic patients with open angle glaucoma after four years.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5084.
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© ARVO (1962-2015); The Authors (2016-present)
To examine the relationship between baseline optic nerve head (ONH) parameters and changes in capillary blood flow in open angle glaucoma (OAG) patients with diabetes mellitus (DM).
79 patients with OAG (16 with DM, 63 without DM) were assessed for capillary blood flow by Heidelberg retinal flowmetry (HRF) and for ONH parameters by Heidelberg retinal tomography 3 (HRT3) every 6 months for a 4-year period. Pearson correlations were used to test for associations between measurements, with p<0.05 considered statistically significant.
In OAG patients with DM, baseline rim area was positively and significantly associated with changes in the percentage of avascular area in the superior (r=0.63, p=0.0079), and inferior retina (r=0.71, p=0.0014), and baseline rim volume was positively and significantly associated with changes in the percentage of avascular area in the superior (r=0.69, p=0.0024), and inferior retina (r=0.78, p=0.0002), leading to a significant difference compared to patients without DM (rim area: superior avascular area p=0.0039, inferior avascular area p=0.0015; rim volume: superior avascular area p=0.0005, inferior avascular area p=0.0000).
Compared to OAG patients without DM, in OAG patients with DM baseline ONH parameters are significantly and positively associated with changes in capillary blood flow after 4 years.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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