July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Optic nerve head morphology at baseline is associated with changes in capillary blood flow in diabetic patients with open angle glaucoma after four years.
Author Affiliations & Notes
  • Alice Chandra Verticchio Vercellin
    Glaucoma Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Fondazione G.B.Bietti, Rome, Italy, Rome, Italy
    University Eye Clinic, Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Fondazione IRCCS, Policlinico San Matteo, Pavia, Italy
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • David Camp
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Aaditya Shah
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Aditya Belamkar
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Sunu Mathew
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Thomas A Ciulla
    Retina Service, Midwest Eye Institute, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   Alice Chandra Verticchio Vercellin, None; Alon Harris, AdOM (C), AdOM (I), CIPLA (C), Nano Retina (I), Oxymap (I); Brent Siesky, None; David Camp, None; Aaditya Shah, None; Aditya Belamkar, None; Sunu Mathew, None; Thomas Ciulla, Ophthotech (I), Spark (I), Spark (E)
  • Footnotes
    Support  Research to Prevent Blindness, NY, NY and American Diabetes Association Grant 1-12-IN-20
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5084. doi:https://doi.org/
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      Alice Chandra Verticchio Vercellin, Alon Harris, Brent A Siesky, David Camp, Aaditya Shah, Aditya Belamkar, Sunu Mathew, Thomas A Ciulla; Optic nerve head morphology at baseline is associated with changes in capillary blood flow in diabetic patients with open angle glaucoma after four years.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5084. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the relationship between baseline optic nerve head (ONH) parameters and changes in capillary blood flow in open angle glaucoma (OAG) patients with diabetes mellitus (DM).

Methods : 79 patients with OAG (16 with DM, 63 without DM) were assessed for capillary blood flow by Heidelberg retinal flowmetry (HRF) and for ONH parameters by Heidelberg retinal tomography 3 (HRT3) every 6 months for a 4-year period. Pearson correlations were used to test for associations between measurements, with p<0.05 considered statistically significant.

Results : In OAG patients with DM, baseline rim area was positively and significantly associated with changes in the percentage of avascular area in the superior (r=0.63, p=0.0079), and inferior retina (r=0.71, p=0.0014), and baseline rim volume was positively and significantly associated with changes in the percentage of avascular area in the superior (r=0.69, p=0.0024), and inferior retina (r=0.78, p=0.0002), leading to a significant difference compared to patients without DM (rim area: superior avascular area p=0.0039, inferior avascular area p=0.0015; rim volume: superior avascular area p=0.0005, inferior avascular area p=0.0000).

Conclusions : Compared to OAG patients without DM, in OAG patients with DM baseline ONH parameters are significantly and positively associated with changes in capillary blood flow after 4 years.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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