A comparison study between Humphrey automated perimetry and fundus automated perimetry Compass in ocular hypertension patients and glaucomatous ones

Abstract

Purpose : Mean Deviation (MD) and Pattern Standard Deviation (PSD) measured with Humphrey (HFA) automated perimetry and fundus automated perimetry Compass (CMP) were evaluated in ocular hypertension (OH) and glaucoma patients. A comparison of the results obtained with the two different perimeters was staged according to Glaucoma Staging System 2 (GSS 2).

Methods : 88 patients were included in the study, 53 with OH and 35 with glaucoma. The patients underwent an ophthalmological visit with evaluation of intraocular pressure (IOP), pachimetry, ocular fundus and optic coherence tomography (OCT). After the enrollment, they underwent two visual field examinations in a random manner: HFA (SITA-standard, program 24-2) and CMP (ZEST strategy, “New Grid”) or viceversa, with an interval of 30’ between the two tests. The results obtained were classified according to GSS 2 and compared with one another for staging levels.

Results : MD values obtained with the two different techniques were similar in both OH patients and glaucoma patients. In OH patients MD was -0,41 dB ± 2,07 with CMP vs -0,38 dB ± 2,4 with HFA while MD in glaucoma patients was -2,77 dB ± 2,64 with CMP vs -2,62 dB ± 3,95 with HFA. The average value of PSD in OH was higher with CMP compared to HFA (2,32 dB ± 1,63 with CMP vs 1,66 dB ± 1,48 with HFA) while it was similar in glaucoma patients (3,82 dB ± 2,78 with CMP vs 3,69 dB ± 2,41 with HFA). An overall comparison of the GSS 2 between the two different perimeters showed that 54,5% of the eyes studied falls into the same stage. When limited to the OH patients, 33% of them tested with CMP falls into a worse stage compared to HFA while an opposite result is present only in 12%.

Conclusions : The two different perimeters showed a good correlation in the diagnosis of glaucomatous damage. The “new Grid” of CMP permits a more accurate study of the areas with a greater density of ganglion cells and it seems to justify the higher PSD values obtained in the OH patients, as a sign of an earlier diagnosis of visual field damage.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.