July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Visual function and ocular morphology in relation to growth and cardiovascular status in 10-year-old children born moderate-to-late preterm
Author Affiliations & Notes
  • Marita Andersson Gronlund
    Pediatric Ophthalmology, Inst Neurosci & Phys/Ophthal, Goteborg, Sweden
  • Alexandra Lind
    Pediatric Ophthalmology, Inst Neurosci & Phys/Ophthal, Goteborg, Sweden
  • Lina Raffa
    Pediatric Ophthalmology, Inst Neurosci & Phys/Ophthal, Goteborg, Sweden
  • Kerstin Allvin
    Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
  • Deala Ghazi Mroué
    Pediatric Ophthalmology, Inst Neurosci & Phys/Ophthal, Goteborg, Sweden
  • Jovanna Dahlgren
    Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden
  • Footnotes
    Commercial Relationships   Marita Gronlund, None; Alexandra Lind, None; Lina Raffa, None; Kerstin Allvin, None; Deala Ghazi Mroué, None; Jovanna Dahlgren, None
  • Footnotes
    Support  Gothenburg Medical Society, the Swedish Society of Medicine, the Cronqvists stiftelse, and Agreement concerning the research and education of doctors (ALFGBG-11626, ALFGBG-211671, ALFGBG-445021, ALFGBG-11869 and ALFGBG-427731).
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5201. doi:
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      Marita Andersson Gronlund, Alexandra Lind, Lina Raffa, Kerstin Allvin, Deala Ghazi Mroué, Jovanna Dahlgren; Visual function and ocular morphology in relation to growth and cardiovascular status in 10-year-old children born moderate-to-late preterm. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5201.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The interest in studying the risks of being born moderate-to-late preterm (MLP) has increased during recent years, however, the ophthalmological aspects are not fully investigated. We performed a prospective, observational clinical study to learn more about visual function and ocular fundus morphology in relation to auxological data, growth factors and blood pressure in MLP children at 10 years of age.

Methods : This longitudinal study was performed in MLP children born in Gothenburg, Sweden, during year 2002–2003. The children were investigated neonatally and followed-up 10 years later. At 10 years of age, 33 children born MLP (10 girls, 23 boys) of whom 9 were born small for gestational age (SGA), were examined. An age- and sex-matched control group consisted of 28 children (9 girls, 19 boys). Main outcomes and measures were visual acuity, refraction and fundus morphology. Auxological data, insulin-like growth factor I (IGF-I), insulin-like growth factor binding protein 3 (IGFBP-3), leptin, adiponectin and blood pressure were measured.

Results : Refractive errors were more commonly found in MLP children compared to controls (p=.006; 95% CI, 9.9-56.6). Furthermore, the MLP group had smaller optic disc area (p=.011; 95% CI, -0.5–(-0.1)), smaller rim area (p=.001; 95% CI, -0.5–(-0.2)), less branching points (p<.001; 95% CI, -5.7–(-2.1)), higher index of tortuosity of arteries (p=.028; 95% CI, 0.002–0.033) and veins (p=.017; 95% CI, 0.003–0.022). Refraction correlated with IGF-I levels (p<.001; r=.60, in right eye, and p=.002; r=.55, in left eye) at 10 years of age. Tortuosity of arteries at assessment correlated with neonatal IGF-I levels (p=.029; r=-.39). Tortuosity of veins was associated with the leptin/adiponectin ratio at assessment (p=.044; r=.37).

Conclusions : The findings suggest that being born MLP is associated with refractive errors, smaller optic disc and rim areas, as well as abnormal retinal vascularization. Moreover, metabolic status and growth factors seem to have an impact on ocular development.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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