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Tomoyuki Okazaki, Susumu Sakimoto, Shinichi Usui, Hirokazu Sakaguchi, Kohji Nishida; Association of unilateral epiretinal membrane is a factor of predominant progression in patients with open-angle glaucoma.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5266.
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Epiretinal membrane (ERM) remains to be unknown as a potential risk factor for primary open-angle glaucoma (POAG). The purpose of this study was to compare glaucoma progression in an eye with or without ERM in the same POAG patient.
Retrospective chart review on 179 consecutive patients with ERM and/or POAG was conducted. ERMs were grouped into 4 stages defined by Govetto et al. according to OCT images. Age, visual acuity, intraocular pressure (IOP), mean deviation (MD) on Humphry field analyzer and the number of anti-glaucoma eye drop scores were evaluated. Predominant cupping in optic disc was evaluated using fundus photograph.
Of 16 patients which met our criteria, mean age was 67.9 ± 8.5 y.o. and the number of male was 9 (56.3%). The number of eyes in each ERM stage was 1 eye in stage 1 (6.3 %), 9 eyes in stage 2 (56.3 %), 4 eyes in stage 3 (25.0 %) and 2 eyes in stage 4 (12.5 %). Mean IOP were 12.7 ± 2.0 mmHg in eyes with ERM (ERM group) and 13.4 ± 2.2 mmHg in eyes without ERM (w/o ERM group) (p=0.25). Predominant optic disc cupping in eyes with ERM compared to fellow eye, namely eyes without ERM was detected in 12 eyes (75.0 %). Fair progression between an eye with ERM and without ERM was detected in 4 eyes (25.0%). Mean MD were -12.2 ± 8.7 dB in ERM group and -6.9 ± 7.2 dB in w/o ERM group (p=0.0398). Eye drop scores was 1 in ERM group and 0 in w/o ERM group (p=0.0156)
Association of ERM might potentiate to worsen glaucoma progression in eyes with POAG.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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