July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Deep Learning for the Prediction of Treatment Indication for Epiretinal Membrane Removal based on Macular OCT Scans
Author Affiliations & Notes
  • Philipp Prahs
    Department of Ophthalmology, University of Regensburg, Regensburg, Germany
  • Caroline Brandl
    Department of Ophthalmology, University of Regensburg, Regensburg, Germany
    Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany
  • Viola Radeck
    Department of Ophthalmology, University of Regensburg, Regensburg, Germany
  • Yordan Cvetkov
    Department of Ophthalmology, University of Regensburg, Regensburg, Germany
  • Christian Mayer
    Department of Ophthalmology, Technical University Munich, Munich, Germany
  • Horst Helbig
    Department of Ophthalmology, University of Regensburg, Regensburg, Germany
  • David Maerker
    Department of Ophthalmology, University of Regensburg, Regensburg, Germany
  • Footnotes
    Commercial Relationships   Philipp Prahs, None; Caroline Brandl, None; Viola Radeck, None; Yordan Cvetkov, None; Christian Mayer, None; Horst Helbig, None; David Maerker, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5271. doi:
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      Philipp Prahs, Caroline Brandl, Viola Radeck, Yordan Cvetkov, Christian Mayer, Horst Helbig, David Maerker; Deep Learning for the Prediction of Treatment Indication for Epiretinal Membrane Removal based on Macular OCT Scans. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5271.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Optical coherence tomography (OCT) scans of the central retina show the anatomy of the vitreoretinal interface in detail and are widely used by clinicians in the decision-making process for pars plana vitrectomy with epiretinal membrane peeling. In recent years, significant progress has been made in artificial intelligence and computer vision research. We trained a deep convolutional artificial neural network to predict treatment indication for vitrectomy with epiretinal membrane peeling based on macular OCT scans without human intervention.

Methods : In a retrospective approach we identified a total of 449 vitrectomies with epiretinal membrane removal from the electronic intervention records of a university hospital. OCT images acquired in a 10 week interval before surgical membrane removal were assigned to the treatment group. A random collection of OCT scans without following surgical procedures constituted the control group. After image preprocessing, OCT images were divided into training and test datasets. We trained a deep convolutional neural network of the Inception V4 type using the Google TensorFlow framework and assessed its performance on OCT scans in the test dataset. We calculated prediction accuracy, sensitivity, specifity and receiver operating characteristics.

Results : A total of 4920 individual OCT B-scans were exported from the institutional image archive and assigned to their respective groups. 4428 images were used to train the neural network classifier. After training the neural network reached a predicition accuracy of 91.9% on the OCT scans of the test dataset. For single retinal B-scans without clinical information a specificity of 95.3% and a sensitivity of 87.8% were achieved. The area under the receiver operating characteristics curve was 0.967 for individual retinal B-scan and 0.978 by averaging over all B-scans of an OCT examination session.

Conclusions : After training with historical clinical data, artificial intelligence systems are effective in generating treatment propositions. Those methods can offer the clinician support in the decision-making process. Care should be taken not to mistake neural network output as treatment recommendation and to ensure a final thorough evaluation by the treating physician.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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