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Didier G Benoit, Stephen Raillard, Stephen Charles, D. Victor Perlroth; A novel biocompatible polymer platform enables customizable small molecule loadings for extended durability and sustained release in ophthalmology. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5320.
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© ARVO (1962-2015); The Authors (2016-present)
Development of a biocompatible polymer platform that can deliver targeted amounts of therapeutic small molecules with enhanced durability.
We are studying co-polymerizations of methacrylate based phosphorylcholine containing monomers with functionalized methacrylate co-monomers to produce branched, high molecular weight, high solubility copolymers with functional handles that are further modified with linkers and small molecule therapeutics.
Co-polymerizations of hydroxyethylmethacrylate based phosphorylcholine with functionalized methacrylate co-monomers in homogenous solutions were successful in generating random copolymers with tight control over molecular weights and polydispersity.
It was shown that a co-polymer-based approach employing hydroxyethylmethacrylate phosphorylcholine and functionalized methacrylate monomers can be used to build well characterized, optically clear co-polymers with a high stoichiometry of loading of small molecule therapeutics. This new platform can be productively applied to the development of novel retinal therapeutics with extended durability.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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