July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Imaging immune cell dynamics in the kidney
Author Affiliations & Notes
  • Michael Hickey
    Centre for Inflammatory Diseases, Monash University, Melbourne, Victoria, Australia
  • Footnotes
    Commercial Relationships   Michael Hickey, None
  • Footnotes
    Support  National Health & Medical Research Council (Australia) Project Grant IDs 1064112 & 1124459, and Senior Research Fellowship ID 1042775
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5342. doi:
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    • Get Citation

      Michael Hickey; Imaging immune cell dynamics in the kidney
      . Invest. Ophthalmol. Vis. Sci. 2018;59(9):5342.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : This presentation will examine the use of state-of-the-art in vivo microscopy techniques such as two-photon and spinning disk confocal microscopy for the discovery of novel behaviours of immune cells in the renal microvasculature. The actions of immune cell subsets including neutrophils, monocytes, T cells and antigen-presenting cells in the glomerular microvasculature will be described under both resting conditions, and following an inflammatory stimulus. The key findings presented will include description of 1) an intravascular mode of vessel injury mediated by both neutrophils and monocytes, and 2) a novel form of intravascular antigen presentation to CD4+ T cells that initiates glomerular injury.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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