July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Mitochondria, exercise, diet and the aging retina
Author Affiliations & Notes
  • Ian A. Trounce
    Center for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia
  • Footnotes
    Commercial Relationships   Ian Trounce, None
  • Footnotes
    Support  NHMRC Grant 1061472; DHB Foundation
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5344. doi:
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      Ian A. Trounce; Mitochondria, exercise, diet and the aging retina. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5344.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : Lifestyle interventions combined with therapeutics that target mitochondria hold great promise for reducing vision loss for both glaucoma and age related macular degeneration. For efficient, clean energy production in the metabolically active retina, balanced renewal (biogenesis) and recycling (mitophagy) of mitochondria must occur. Positive effects of exercise, fasting, and some dietary supplements converge on this pathway of mitochondrial quality control. Conversely aging, overnutrition or lack of exercise impair mitophagy, leading to energetic failure and oxidative stress. Recent research insights and remaining gaps will be highlighted, with a focus on glaucoma.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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