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Emily Y. Chew; Genetic Interactions between Diet and Oral Supplements in Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5346.
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Presentation Description :
The association of diet with age-related macular degeneration (AMD) has been of great interest since 1988 when the National Health And Nutritional Examination Survey (NHANES) results demonstrated an inverse relationship between diet rich in vitamins and the prevalence of AMD. Numerous studies have subsequently supported the role of healthy diet in AMD. The results of the Age-Related Eye Disease Study (AREDS) and AREDS2 have also demonstrated the importance of micronutrient supplementation in AMD.The discovery of complement factor H (CFH) in 2005 had marked an explosion of genetic information associated with AMD. The following year, ARMS2 genetic association was firmly established as the other important genetic marker for AMD. By 2016, a large international consortium that studied more than 16,000 affected individuals with approximately 17,800 controls demonstrated that 52 independently associated common and rare variants found in 34 loci were associated with AMD.The interaction of genetics with diet and oral supplements have been studied by several groups of investigators in this area. This presentation will evaluate some of the recent findings from analyses of the AREDS and AREDS2 genetic and nutritional data, both dietary and supplementary. Can one eat away one's genetic risk for AMD?
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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