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Keijiro Ishikawa, Shigeo Yoshida, Yuki Kubo, Yoshiyuki Kobayashi, Takahito Nakama, Yusuke Murakami, Yasuhiro Ikeda, Shintaro Nakao, Koh-hei Sonoda; Increased Expression of Periostin and Tenascin-C in the Aqueous Humor in Neovascular Glaucoma secondary to PDR. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5376.
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© ARVO (1962-2015); The Authors (2016-present)
We previously reported periostin (PN) and tenascin-C (TNC-C), matricellular proteins, play significant roles in the pathogenesis of preretinal fibrovascular proliferation associated with proliferative diabetic retinopathy (PDR). The purpose of this study was to investigate the expression of PN and TNC-C in the aqueous humor of patients with neovascular glaucoma (NVG) secondary to PDR.
This study enrolled 29 eyes of 27 patients who were grouped into (1) NVG (NVG; n=6); (2) PDR without NVG (PDR; n=6); (3) primary open-angle glaucoma (POAG; n=8) and (4) cataract surgery patients as a control group (CG; n =9). None of the patients underwent advanced ocular treatment including anti-VEGF therapy or surgery. Aqueous humor samples were collected from the anterior chamber at the start of surgery or intravitreal injection of anti-VEGF drug. The protein concentrations of PN and TNC-C in the aqueous humor were measured by ELISA. Tukey-Kramer honestly significant difference test was used for multiple comparisons.
The levels of PN and TNC-C were all under detection level in POAG group and CG. NVG group had significantly higher level of PN compared to PDR group. (109.9 ng/ml vs 2.1 ng/ml; p<0.05) The average level of TNC-C was higher in NVG group compared to PDR group with no significant difference. (18.5 ng/ml vs 4.6 ng/ml; p=0.134). There was a significant correlation between the levels of PN and TNC-C in NVG group (r=0.86, p<0.05).
Our data suggest that increased expression of PN and TNC-C can play a role in fibrovascular proliferation in eyes with NVG secondary to PDR.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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