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Signe Krejberg Jeppesen, Toke Bek; The increased arterial oxygen saturation in branch retinal vein occlusion depends on the size of the affected retinal area. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5431.
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© ARVO (1962-2015); The Authors (2016-present)
Branch retinal vein occlusion (BRVO) has been shown to be accompanied with increased oxygen saturation in arterioles supplying retinal tissue which is ischemic secondary to vein occlusion. However, it is unknown whether this response depends on the size of the retinal area affected by the occlusion. This might be studied by comparing oxygen saturations from patients with BRVO and with macular retinal vein occlusion (MRVO).
Twenty-nine consecutive patients aged (mean, range) 70.6, 42-91 years with temporal (BRVO) and 24 consecutive patients aged (mean, range) age 68.4, 47-89 years with MRVO referred to the Department of Ophthalmology, Aarhus University Hospital, were studied. In addition to a routine ophthalmological examination, oximetry (Oxymap, model T1, Oxymap, Reykjavik, Iceland) was performed with the optic disc in the center. The oxygen saturations in the arterial and venous temporal branches supplying the affected, and the opposite temporal vessels as well the temporal vessels on the contralateral eye were collected.
All results are indicated as mean±SEM. In eyes affected by BRVO the arterial oxygen saturation was 100.8±2.03% which was significantly higher (p=0.04) than the saturation in the opposite temporal arteriole in the same eye (96.39±1.32%), while the venous oxygen saturation in the occluded venule (61.48±3.29%) was not significantly different (p=0.22) from the saturation in the opposite temporal vessel in the same eye (61.74±1.94%). In the retinal area affected by MRVO neither the arterial nor the venous oxygen saturations differed significantly between the affected and the unaffected areas, 95.97±1.57% vs. 97.41±1.49% (p=0.58) and 61.15±2.65% vs. 63.04±2.38% (p=0.56), respectively. There were no significant differences between the oxygen saturation in the temporal vessels opposite to the occlusion in the affected eyed and in the vessels in the contralateral eye (p>0.13 for all comparisons).
Increased oxygen saturation in arterioles supplying retinal tissue ischemic secondary to vein occlusion may be contribute to the development of late complications frequent in BRVO but not MRVA, such as e.g. retinal neovascularization.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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