Abstract
Purpose :
To analyze microvascular changes of retinal vein occlusion patients using optical coherence tomography angiography(OCTA) before and after anti-vascular endothelial growth factor(VEGF) therapy
Methods :
Retrospective review of medical record of patients with secondary macular edema to retinal vein occlusion treated with anti-VEGF and a minimum follow-up of 3 months. Best-corrected visual acuity(BCVA), central retinal thickness(CRT) were assessed before and after treatment. The area of capillary non-perfusion, foveal avascular area, vessel density and perfusion index was evaluated with OCTA
Results :
The study analyzed 40 eyes of 40 patients (mean ages, 65.4 years), including 11 cases of central RVO, 23 cases of branch RVO and 6 cases of hemi-central RVO. All patients received anti-VEGF treatment of RVO with secondary macular edema at least once more intravitreal injection. The mean follow-up period was 5.5 months. At final visit, the logMAR BCVA significantly improved from 0.51±0.13 to 0.28±0.17 (p<0.001) and mean central retinal thickness significantly decreased from 405.13±142.02μm to 294.50±102.73μm (p<0.001). The disruption of perifoveal capillary, the number of intraretinal cyst and venous dilatation in retinal superficial and deep capillary layers on OCTA was significantly decreased after treatment using OCTA. The area of capillary non-perfusion after treatment was decreased rather than baseline
Conclusions :
The study showed improvement of impaired retinal vascular flow and areas of capillary non-perfusion after anti-VEGF treatment on OCTA. OCTA may offer effective and non-invasive diagnostic tool for RVO with especially observing microvascular changes including capillary perfusion status
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.