July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Macular function in Early and Intermediate Age-related Macular Degeneration (AMD): effect of systemic risk factors
Author Affiliations & Notes
  • Angelo Maria Minnella
    Ophthalmology, Università Cattolica S. Cuore Fondazione Policlinico A. Gemelli, Rome, Italy
  • Benedetto Falsini
    Ophthalmology, Università Cattolica S. Cuore Fondazione Policlinico A. Gemelli, Rome, Italy
  • marco piccardi
    Ophthalmology, Università Cattolica S. Cuore Fondazione Policlinico A. Gemelli, Rome, Italy
  • Footnotes
    Commercial Relationships   Angelo Minnella, None; Benedetto Falsini, None; marco piccardi, None
  • Footnotes
    Support  Italian Ministry of Research and Education Grant D3 to B.F. Università Cattolica del Sacro Cuore
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5549. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Angelo Maria Minnella, Benedetto Falsini, marco piccardi; Macular function in Early and Intermediate Age-related Macular Degeneration (AMD): effect of systemic risk factors. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5549. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To evaluate the influence of systemic risk factors on macular function in early to intermediate macular degeneration (AMD)

Methods : In a prospective study, focal macular electroretinograms (fERGs, 18 deg, 41 Hz) were recorded from a cohort of 140 AMD patients (M/F: 60/80, age 55-87 yrs), who underwent a long term 5 years clinical ophthalmic and general follow-up. Sixty-five patients had early and 75 intermediate AMD. Early neovascularization or impending geographic atrophy patients were excluded. fERG amplitude and phase were the main outcome variables

Results : Multivariate analysis of variance showed that, after correction for age (p < 0.001) and AMD stage (p < 0.05) as covariates, smoking history and systemic hypertension had no effect, while non-insulin dependent (NID) diabetes (even with less than 5 years duration) negatively impacted on fERG amplitude (p < 0.02)

Conclusions : In a multivariate model evaluating the effect of systemic risk factors on central fERG in early and intermediate AMD, even a NID diabetes of short duration negatively influences macular function, suggesting its prominent role on early stages of disease progression

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×