July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Ethnic differences in presenting characteristics and visual acuity outcomes of neovascular age-related macular degeneration within an urban tertiary ophthalmic hospital
Farid Afshar; Siegfried Wagner; Katrin Fasler; Reena Chopra; Karsten Ulrich Kortuem; Nikolas Pontikos; Thushanthi Ramakrishnan; GABRIELLA CLAIRE PRESTON; Konstantinos Balaskas; Adnan Tufail; Praveen Patel; Pearse Keane
Author Affiliations & Notes
  • Farid Afshar
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK, London, United Kingdom
  • Siegfried Wagner
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK, London, United Kingdom
  • Katrin Fasler
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK, London, United Kingdom
  • Reena Chopra
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK, London, United Kingdom
  • Karsten Ulrich Kortuem
    University Eye Hospital Munich, Munich, Germany
  • Nikolas Pontikos
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK, London, United Kingdom
  • Thushanthi Ramakrishnan
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK, London, United Kingdom
  • GABRIELLA CLAIRE PRESTON
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK, London, United Kingdom
  • Konstantinos Balaskas
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK, London, United Kingdom
    University of Manchester, London, United Kingdom
  • Adnan Tufail
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK, London, United Kingdom
  • Praveen Patel
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK, London, United Kingdom
  • Pearse Keane
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK, London, United Kingdom
  • Footnotes
    Commercial Relationships   Farid Afshar, None; Siegfried Wagner, None; Katrin Fasler, Alfred Vogt Stipendium (F), Schweizerischer Fonds zur Verhütung und Bekämpfung der Blindheit (F); Reena Chopra, None; Karsten Kortuem, Alcon (R), Allergan (R), Bayer (F), Bayer (R), Big Picture (C), Google Deepmind (C), Novartis (F); Nikolas Pontikos, None; Thushanthi Ramakrishnan, None; GABRIELLA PRESTON, Bayer (R), City, University of London (E); Konstantinos Balaskas, Bayer (R), Heidelberg (R), Novartis (C), Novartis (R), Topcon (R); Adnan Tufail, Allergan (C), Bayer (C), Genentech (C), Heidelberg Engineering (C), Novartis (C), Novartis (F), Roche (C); Praveen Patel, Bayer (C), Genetech (C), Heidelberg (F), Merk (C), Novartis (C), Roche UK (C), SalutarisMD (R), Thrombogenics NV (C), Thrombogenics NV (F), Topcon (F); Pearse Keane, Allergan (R), Bayer (R), Google (C), Haag-Streit (R), Heidelberg Engineering (R), Novartis (R), Topcon (R), Zeiss (R)
  • Footnotes
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Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5550. doi:
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      Farid Afshar, Siegfried Wagner, Katrin Fasler, Reena Chopra, Karsten Ulrich Kortuem, Nikolas Pontikos, Thushanthi Ramakrishnan, GABRIELLA CLAIRE PRESTON, Konstantinos Balaskas, Adnan Tufail, Praveen Patel, Pearse Keane; Ethnic differences in presenting characteristics and visual acuity outcomes of neovascular age-related macular degeneration within an urban tertiary ophthalmic hospital. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5550.

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Abstract

Purpose : Epidemiological studies of age-related macular degeneration (AMD) suggest that there are ethnic differences between disease prevalence. In this retrospective study, we describe the age, gender, ethnic distribution and 12 month visual outcomes of those diagnosed with neovascular AMD at a Moorfields Eye Hospital, London.

Methods : The Moorfields Eye Hospital Electronic Medical Record (EMR) system was queried for presenting age, gender, ethnicity, baseline and 12 month visual acuity of patients undergoing anti-VEGF treatment (aflibercept and/or ranibizumab, depending on valid protocol) for neovascular AMD between 2007 and 2017. Missing data were manually added to the dataset. Statistical analysis was carried out using SPSS version 23.

Results : Of the 5,614 patients of the Moorfields AMD-cohort, the mean (SD) age was 79 (±9) years at presentation, and of these 61.4% were female. Ethnicity was reported in 99.7% of patients: 3,717 (66.2%) patients were White, 463 (8.2%) patients Asian, 71 (1.3%) patients were Black, 34 (0.6%) were Chinese, and 1,387 (23.4%) were mixed/other. Baseline visual acuity was 56.1 (±16) letters for patients who were White, 54.5 (±17) letters for patients who were Black, 55.5 (±20) letters for Asian and 54.9 (±16) for those of mixed/other ethnicity. Twelve month visual acuity showed a gain of 4.5 letters (±15) letters for patients who were White, 7.6 (±17) letters for patients who were Black, 4.3 (±14) letters for Asian and 5.1 (±14) for those of mixed/other ethnicity.

Conclusions : According to the national census 2011, where 13.3% of Londoners were black, only 1.3% of the patients in our cohort were black. These data indicates that the Asian cohort may have slightly worse visual outcome after 12 months, however the differences in visual gain after 12 months was similar in all groups, except for blacks, which represent 1.3% of the whole cohort. Differences in the ethnic populations in the location of Moorfields satellite sites may also account for the ethnic proportions observed in this cohort.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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