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Farid Afshar, Siegfried Wagner, Katrin Fasler, Reena Chopra, Karsten Ulrich Kortuem, Nikolas Pontikos, Thushanthi Ramakrishnan, GABRIELLA CLAIRE PRESTON, Konstantinos Balaskas, Adnan Tufail, Praveen Patel, Pearse Keane; Ethnic differences in presenting characteristics and visual acuity outcomes of neovascular age-related macular degeneration within an urban tertiary ophthalmic hospital. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5550.
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© ARVO (1962-2015); The Authors (2016-present)
Epidemiological studies of age-related macular degeneration (AMD) suggest that there are ethnic differences between disease prevalence. In this retrospective study, we describe the age, gender, ethnic distribution and 12 month visual outcomes of those diagnosed with neovascular AMD at a Moorfields Eye Hospital, London.
The Moorfields Eye Hospital Electronic Medical Record (EMR) system was queried for presenting age, gender, ethnicity, baseline and 12 month visual acuity of patients undergoing anti-VEGF treatment (aflibercept and/or ranibizumab, depending on valid protocol) for neovascular AMD between 2007 and 2017. Missing data were manually added to the dataset. Statistical analysis was carried out using SPSS version 23.
Of the 5,614 patients of the Moorfields AMD-cohort, the mean (SD) age was 79 (±9) years at presentation, and of these 61.4% were female. Ethnicity was reported in 99.7% of patients: 3,717 (66.2%) patients were White, 463 (8.2%) patients Asian, 71 (1.3%) patients were Black, 34 (0.6%) were Chinese, and 1,387 (23.4%) were mixed/other. Baseline visual acuity was 56.1 (±16) letters for patients who were White, 54.5 (±17) letters for patients who were Black, 55.5 (±20) letters for Asian and 54.9 (±16) for those of mixed/other ethnicity. Twelve month visual acuity showed a gain of 4.5 letters (±15) letters for patients who were White, 7.6 (±17) letters for patients who were Black, 4.3 (±14) letters for Asian and 5.1 (±14) for those of mixed/other ethnicity.
According to the national census 2011, where 13.3% of Londoners were black, only 1.3% of the patients in our cohort were black. These data indicates that the Asian cohort may have slightly worse visual outcome after 12 months, however the differences in visual gain after 12 months was similar in all groups, except for blacks, which represent 1.3% of the whole cohort. Differences in the ethnic populations in the location of Moorfields satellite sites may also account for the ethnic proportions observed in this cohort.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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