July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Association of Age-related Macular Degeneration with Retinal Vascular Caliber in Patients with the Acquired Immunodeficiency Syndrome
Author Affiliations & Notes
  • Douglas A Jabs
    Icahn School of Medicine at Mount Sinai, New York, New York, United States
    Johns Hopkins University Bloomberg School of Public Health, Baltimore , Maryland, United States
  • Mark L. Van Natta
    Johns Hopkins University Bloomberg School of Public Health, Baltimore , Maryland, United States
  • Jeong W Pak
    University of Wisconsin School of Medicine and Public Health, Madison , Wisconsin, United States
  • Ronald P Danis
    University of Wisconsin School of Medicine and Public Health, Madison , Wisconsin, United States
  • Peter Hunt
    University of California, San Francisco School of Medicine, San Francisco, California, United States
  • Footnotes
    Commercial Relationships   Douglas Jabs, None; Mark Van Natta, None; Jeong Pak, None; Ronald Danis, None; Peter Hunt, None
  • Footnotes
    Support  Supported by grant R01 EY025903 from the National Eye Institute, the National Institutes of Health, Bethesda, MD, USA.
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5564. doi:https://doi.org/
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      Douglas A Jabs, Mark L. Van Natta, Jeong W Pak, Ronald P Danis, Peter Hunt; Association of Age-related Macular Degeneration with Retinal Vascular Caliber in Patients with the Acquired Immunodeficiency Syndrome. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5564. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Patients with the acquired Immunodeficiency syndrome (AIDS) have an ~4-fold increased prevalence and an ~1.75-fold increased incidence of intermediate-stage age-related macular degeneration (AMD) compared to HIV-uninfected persons. We investigated the relationship between retinal vascular caliber and AMD among participants enrolled in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA).

Methods : Participants enrolled in LSOCA had retinal photographs taken at enrollment. Photographs were evlauated at a reading center for intermediate-stage AMD using the AREDS grading system and for retinal vascular caliber using published, semi-automated techniques. Retinal vascular caliber measurements were reported as the central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE).

Results : Of the 1171 participants evaluated, 110 (9.4%) had AMD and 1061 (90.6%) did not have AMD. Participants with AMD had larger mean CRAE (151 ± 16 μm) than participants without AMD (147± 16 μm, P=0.009) and larger mean CRVE (228 ± 24 μm) than participants without AMD (223 ± 25 μm, P=0.02). After adjustment for age, race/ethnicity, gender, human immunodeficiency virus (HIV) transmission category, smoking, enrollment and prior nadir CD4+ T cell counts, and enrollment and prior maximum HIV load, the differences between participants with and without AMD were: CRAE, 5.4 μm (95% CI 2.3, 8.5; P=0.001) and CRVE, 6.0 μm (95% CI 1.4, 10.6; P=0.01).

Conclusions : In patients with AIDS, AMD is associated with dilated retinal vessels, both arterioles and venules, suggesting a role for shared pathogenetic mechanisms, such as persistent systemic inflammation.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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