July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Fungus-specific IgG in patients with allergic conjunctivitis
Author Affiliations & Notes
  • Tatsuya Mimura
    Ophthalmology,, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan
  • Emiko Watanabe
    Ophthalmology,, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan
  • Atsushi Mizota
    Ophthalmology,, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Tatsuya Mimura, None; Emiko Watanabe, None; Atsushi Mizota, None
  • Footnotes
    Support  a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (16K11332).
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5570. doi:
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    • Get Citation

      Tatsuya Mimura, Emiko Watanabe, Atsushi Mizota; Fungus-specific IgG in patients with allergic conjunctivitis. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5570.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Seasonal allergy is due to a type I immediate hypersensitivity reaction mediated by immunoglobulin (Ig) E, while perennial allergy may be triggered by IgG antibody that mediates type II and type III hypersensitivity reactions to a specific indoor allergen such as house dust mites and fungus. IgG act as an important mediator of host defenses against infection and increase with chronic inflammation. We evaluated the relation between perennial allergic conjunctivitis and serum levels of specific IgG antibodies for fungus to examine the role of IgG in perennial allergy.

Methods : 40 patients with perennial allergic conjunctivitis (allergic group) and 20 healthy subjects (control group) were enrolled in this study. Serum levels of specific IgE and IgG antibodies for Alternaria, Aspergillus, Cladosporium, and Penicillium were measured. A skin prick test for each fungus antigen was also performed. Changes of the palpebral/bulbar conjunctiva and limbal or corneal lesions associated with allergic conjunctivitis were assigned a score (0-3), and the total severity conjunctivitis score was calculated (0-30).

Results : Serum levels of all fungus-specific IgE and IgG antibodies were higher in the allergic group than in the control group, as were the skin prick test for each fungus antigen (all p<0.05). The serum level of each fungus-specific IgG was significantly correlated with the mean wheal diameter in the skin prick test (Alternaria; r=0.95, Aspergillus r=0.95, Cladosporium r=0.96, and Penicillium r=0l97, all p<0.05), and the total conjunctivitis score (Alternaria; r=0.35, Aspergillus; r=0.43, Cladosporium; r=0.41 and Penicillium; r=0.45, all p<0.05). Furthermore the results of skin prick test and the total severity conjunctivitis score were strongly correlated with IgG rather than IgE.

Conclusions : The each serum fungus IgG antibody level was more closely associated with allergic manifestations than the fungus IgE antibody level. Measurement of specific IgG antibodies may be helpful for detecting allergens responsible for allergic diseases. It is known that the barrier to infection decreases with increasing allergic inflammation, and our results may suggest a relationship between allergic inflammation and hypersensitive inflammation against fungus infection.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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