July 2018
Volume 59, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2018
Analysis of clinical features of primary vitreoretinal lymphoma followed for over 5 years
Author Affiliations & Notes
  • Kinya Tsubota
    Ophthalmology, Tokyo Medical University, Shinjuku, Tokyo, Japan
  • Yoshihiko Usui
    Ophthalmology, Tokyo Medical University, Shinjuku, Tokyo, Japan
  • Kazuhiko Umazume
    Ophthalmology, Tokyo Medical University, Shinjuku, Tokyo, Japan
  • Rei Nemoto
    Ophthalmology, Tokyo Medical University, Shinjuku, Tokyo, Japan
  • Motoko Shibata
    Ophthalmology, Tokyo Medical University, Shinjuku, Tokyo, Japan
  • Hiroshi Goto
    Ophthalmology, Tokyo Medical University, Shinjuku, Tokyo, Japan
  • Footnotes
    Commercial Relationships   Kinya Tsubota, None; Yoshihiko Usui, None; Kazuhiko Umazume, None; Rei Nemoto, None; Motoko Shibata, None; Hiroshi Goto, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5583. doi:https://doi.org/
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      Kinya Tsubota, Yoshihiko Usui, Kazuhiko Umazume, Rei Nemoto, Motoko Shibata, Hiroshi Goto; Analysis of clinical features of primary vitreoretinal lymphoma followed for over 5 years. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5583. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Primary vitreoretinal lymphoma (PVRL) is the most common intraocular lymphoma occurring in the eye. Majority of the patients with PVRL develop central nerve system lymphoma (CNSL) within a few years and thereby a poor prognosis. Although five-year survival rate of PVRL has been reported to be approximately 60%, clinical data of long-term survival is unclear because periodical follow up is difficult once CNSL occurred. In this study, we analyzed the clinical features of patients with PVRL who could followed for long time.

Methods : We analyzed the clinical features of 14 patients diagnosed with PVRL who were able to be followed for longer than 5 years from 1994 to 2011 at the Department of Ophthalmology, Tokyo Medical University Hospital. This retrospective study was based on review of medical records.

Results : Of the 14 patients (3 males, 11 females; mean age, 63.8 ± 6.3 years; mean follow-up duration, 90.3±27.9 months), 7 (50%) had unilateral PVRL and 7 (50%) had bilateral PVRL as onset. Thirteen patients (93%) developed CNSL during the follow-up period. The average of overall survival from onset was 7.6 years (range, 5.1-14.1 years). The average of progression free survival from onset was 24.8 months (range, 2-79 months). The average period between onset of PVRL and developing of CNSL was 34.1 months (range, 15-84 months). The average number of relapses during follow-up was 3.7 (range, 0-18); comprising 2.1 (0-16) in eyes and 1.2 (0-3) in CNSL and 0.4 (0-2) in other organs.

Conclusions : Periodical and careful follow-up is critical for patients with PVRL because intra-ocular and CNS relapses are common even in patients who survive long-term.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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