July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Clinical differentiation of non-Hodgkin orbital lymphoma and idiopathic orbital inflammation
Author Affiliations & Notes
  • Kamil Gabriël Laban
    Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands
    Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
  • Richard van Aarle
    Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands
  • Jonas Kuiper
    Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands
    Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
  • Joke de Boer
    Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands
  • Rachel Kalmann
    Ophthalmology, University Medical Center Utrecht, Utrecht, Netherlands
  • Footnotes
    Commercial Relationships   Kamil Laban, None; Richard van Aarle, None; Jonas Kuiper, None; Joke de Boer, None; Rachel Kalmann, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5585. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Kamil Gabriël Laban, Richard van Aarle, Jonas Kuiper, Joke de Boer, Rachel Kalmann; Clinical differentiation of non-Hodgkin orbital lymphoma and idiopathic orbital inflammation
      . Invest. Ophthalmol. Vis. Sci. 2018;59(9):5585.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Non-Hodgkin orbital lymphoma (NHOL) and idiopathic orbital inflammation (IOI) can be difficult to differentiate due to overlapping clinical, radiological and laboratory features. Additionally, orbital biopsies are not always possible for deep localizations. Differentiation is necessary for adequate and timely treatment. In this retrospective study, we investigate the potential of clinical discriminating features within these diseases and we aim to develop a set of clinical features that can be used as a simple differentiating tool in the diagnosis of NHOL and IOI.

Methods : We retrospectively investigated clinical features of 234 adult patients diagnosed with NHOL or IOI between 2000 and 2017 in the University Medical Center Utrecht. We statistically analyzed clinical patient- and disease characteristics using a multivariable logistic regression. A set of discriminating features was tested for correct classification using a receiver operator characteristic curve.

Results : We included 82 patients with NHOL and 152 patients with IOI in this study. Age of disease onset, the presence of pain, eyelid edema, ptosis and proptosis showed statistically significant differences between NHOL and IOI (all p<0.01), with a combined classification power (area under the curve) of more than 90% (p<0.01).

Conclusions : Clinical features are important in the diagnostic process of NHOL and IOI. Using a set of simple features including age, presence of pain, diplopia, eyelid edema, ptosis and proptosis, a differentiation between NHOL and IOI can be made with high accuracy. A multicenter replication is needed to validate these results.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×