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Bipasha Mukherjee, Sugavaneswari G; Ultrasound Guided Intralesional Injection of Bleomycin for Orbital Lymphangioma- A prospective study.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5620. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
Lymphangiomas of the orbit are venolymphatic malformations causing unsightly proptosis, retrobulbar hemorrhage, and even blindness. Management of these infiltrative lesions is extremely difficult. This study was conducted to evaluate the efficacy of intralesional injection of bleomycin in orbital lymphangiomas under guidance of real time imaging.
Patients presenting with deep orbital lymphangiomas from September 2015 to 2017 were enrolled in this prospective, non comparative, interventional study. Intralesional injection of reconstituted bleomycin(0.5IU/kg body weight) was administered under ultrasound guidance to 15 patients. The procedure was repeated as and when required, after 4 weeks, based on clinical and imaging findings. Patients with less than six weeks follow up were excluded from the study.
The mean age of these patients was 11.2years(range-2-29);8 were male while 7 were female. Patients were treated with 1-3 injections of intralesional bleomycin under ultrasound guidance under general anesthesia in children or topical anesthesia in adults.Follow up ranged from 2-17months.All patients presented with proptosis; among which clinical and radiological improvement were noted in 14(93%).None had any significant complication.
Ultrasonography guided intralesional bleomycin can be utilized for safe and accurate delivery of sclerotherapy into orbital lymphangioma.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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