July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Anatomic Feature of the Limbus Differs between Chinese and United States Populations
Author Affiliations & Notes
  • Qihua Le
    Stein Eye Institute, UCLA, Los Angeles, California, United States
    Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China
  • Daniel Cordova
    Stein Eye Institute, UCLA, Los Angeles, California, United States
  • Jianjiang Xu
    Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China
  • Sophie X. Deng
    Stein Eye Institute, UCLA, Los Angeles, California, United States
  • Footnotes
    Commercial Relationships   Qihua Le, None; Daniel Cordova, None; Jianjiang Xu, None; Sophie Deng, Chiesi Farmaceutici S.p.A (C)
  • Footnotes
    Support  grant support from National Eye Institute grants (5P30EY000331 and 1R01EY021797), California Institute for Regenerative Medicine (TR2-01768, CLIN1-08686), and an unrestricted grant from Research to Prevent Blindness
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5715. doi:
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      Qihua Le, Daniel Cordova, Jianjiang Xu, Sophie X. Deng; Anatomic Feature of the Limbus Differs between Chinese and United States Populations. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5715.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To compare the limbal structure and limbal epithelial thickness (LET) between a Chinese Han population and a population in the United States using anterior segment optical coherence tomography (AS-OCT).

Methods : Sixty healthy Chinese subjects (109 eyes, group I) and 39 normal subjects in the United States (65 eyes, group II) were included in this observational comparative study. The central cornea and the superior, inferior, nasal, and temporal limbus of each subject underwent Fourier-domain AS-OCT. Corneal epithelial thickness (CET), the width of limbus, distance between the scleral spur and the thickest part of limbal epithelium (S-T), limbal epithelial area between scleral spur and the end of Bowman's layer (LEA) , the maximum LET and the mean LET were measured.

Results : The width of limbus was 34.6%, 31.7%, 36.5%, and 34.0% greater in the superior, inferior, nasal and temporal limbus, respectively, in the US group than in the Chinese group. S-T and LEA were also significantly higher in all limbal quadrants in the US group (all P<0.001). The maximum LET and mean LET were 11% and 8.1% thicker at the nasal limbus and 8.1% and 6.0% thicker in the temporal limbus in the US group than in the Chinese group.

Conclusions : Compared with the Chinese group, the US group had a wider limbus in all quadrants and thicker limbal epithelium in the nasal and temporal quadrants. Investigators conducting studies of the limbus and surgeons performing procedures with the limbal area involved should take into consideration of these anatomic differences.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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