July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
In open angle glaucoma patients with diabetes mellitus longitudinal changes in central corneal thickness are associated with changes in optic nerve head morphology.
Author Affiliations & Notes
  • David Camp
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Thomas A Ciulla
    Retina Service, Midwest Eye Institute, Indianapolis, Indiana, United States
  • Alice Chandra Verticchio Vercellin
    Glaucoma Unit, Istituto di Ricovero e Cura a Carattere Scientifico, Fondazione G.B.Bietti, Rome, Italy
    University Eye Clinic, Dipartimento di Scienze Clinico-Chirurgiche, Diagnostiche e Pediatriche, Pavia, Italy
  • Aaditya Shah
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Priyanka Parekh
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Marie-Caroline Antheriou
    Ophthalmology, Universitary Hospitals of Geneva, Geneva, Switzerland
  • Brent A Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Footnotes
    Commercial Relationships   David Camp, None; Alon Harris, AdOM (C), AdOM (I), CIPLA (C), Nano Retina (I), Oxymap (I); Thomas Ciulla, Ophthotech (I), Spark (I), Spark (E); Alice Chandra Verticchio Vercellin, None; Aaditya Shah, None; Priyanka Parekh, None; Marie-Caroline Antheriou, None; Brent Siesky, None
  • Footnotes
    Support  Research to Prevent Blindness, NY, NY and American Diabetes Association Grant 1-12-IN-20
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5895. doi:
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      David Camp, Alon Harris, Thomas A Ciulla, Alice Chandra Verticchio Vercellin, Aaditya Shah, Priyanka Parekh, Marie-Caroline Antheriou, Brent A Siesky; In open angle glaucoma patients with diabetes mellitus longitudinal changes in central corneal thickness are associated with changes in optic nerve head morphology.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5895.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To examine the relationship between changes from baseline to 4 years in central corneal thickness (CCT) and changes in optic nerve head (ONH) morphology in open angle glaucoma (OAG) patients with diabetes mellitus (DM).

Methods : 72 patients with OAG (14 with DM, 58 without DM) were assessed for CCT by ultrasound pachymetry and for ONH morphology by Heidelberg retinal tomography 3 (HRT3) and optical coherence tomography (OCT) every 6 months for a 4-year period. Pearson correlations were used to test for associations between measurements, with p<0.05 considered statistically significant.

Results : In OAG patients with DM, changes in CCT were negatively and significantly associated with changes in OCT disk area, OCT rim area, and positively and significantly associated with changes in OCT cup/disk vertical ratio, HRT3 cup volume, HRT3 mean cup depth and HRT3 max cup depth (OCT disk area: r=-0.61, p=0.0185; OCT rim area: r=-0.69, p=0.0051; OCT cup/disk vertical ratio: r=0.64, p=0.0119; HRT3 cup volume: r=0.58, p=0.0267; HRT3 mean cup depth: r=0.65, p=0.0106; HRT3 max cup depth: r=0.65, p=0.0101) leading to a significant difference compared to patients without DM (OCT disk area: p=0.0165; OCT rim area: p=0.0013; OCT cup/disk vertical ratio: p=0.0034; HRT3 cup volume: p=0.0060; HRT3 mean cup depth: p=0.0062; HRT3 max cup depth: p=0.0080).

Conclusions : In OAG patients with DM, longitudinal changes in CCT are significantly associated with changes in ONH morphology after 4 years, compared to OAG patients without DM.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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