July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Spiking Noise in V2 Neurons in Infants Monkeys
Author Affiliations & Notes
  • Bin Zhang
    College of Optometry, Nova Southeastern University , Plantation, Florida, United States
    College of Optometry, University of Houston, Houston, Texas, United States
  • Ye Wang
    College of Optometry, University of Houston, Houston, Texas, United States
  • Xiaofeng Tao
    Baylor College of Medicine, Houston, Texas, United States
  • Guofu Shen
    Baylor College of Medicine, Houston, Texas, United States
  • Janice Marie Wensveen
    College of Optometry, University of Houston, Houston, Texas, United States
  • Earl L Smith
    College of Optometry, University of Houston, Houston, Texas, United States
  • Yuzo M Chino
    College of Optometry, University of Houston, Houston, Texas, United States
  • Footnotes
    Commercial Relationships   Bin Zhang, None; Ye Wang, None; Xiaofeng Tao, None; Guofu Shen, None; Janice Wensveen, None; Earl Smith, None; Yuzo Chino, None
  • Footnotes
    Support  NIH/NEI R01 EY-00812, EY-003611, CORE grant EY-007551
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5955. doi:
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      Bin Zhang, Ye Wang, Xiaofeng Tao, Guofu Shen, Janice Marie Wensveen, Earl L Smith, Yuzo M Chino; Spiking Noise in V2 Neurons in Infants Monkeys. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5955.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : The spiking of neurons in visual area V2 of amblyopic monkeys raised with monocular defocus is noisy. There is increased irregularity of spike intervals at high contrast and elevated trial-to-trial fluctuation of spike counts at low contrast. However, it is not clear whether this noisy spiking is resulted from active disruptions of developing cortical connections due to abnormal visual experience, or from passive freezing of the immature state of cortical connections in infant. Therefore, in this study, therefore, we analyzed the spike trains of V2 neurons in 4- and 8-week-old normal infant monkeys.

Methods : Single unit recording was performed in visual area 2 of anesthetized monkeys. We recorded 178 neurons from infant monkeys and 224 neurons from adult monkeys. We quantified the spiking noise (variability) in response to brief (640 ms) sine wave gratings that were optimized for orientation and spatial frequency for each unit and varied for contrast between 5% and 80%. To assess spiking noise, we quantified the irregularity in spike interval by calculating the square of the coefficient of variation (CV2) and the trial-to-trial variability of the spike count by calculating the mean-matched Fano factor (FF) for individual neurons.

Results : The spiking noise of V2 neurons in infant monkeys was significantly lower than that of the normal adult monkeys. Both the magnitude of spiking irregularity (CV2) and the trial-to-trial fluctuation (m-FF) was lower in spike trains of V2 neurons in infant monkeys than those in normal adult monkeys for all stimulus contrasts.

Conclusions : Our results suggest that the increased spiking noise in V2 neurons of amblyopic adult monkeys does not reflect an arrested development of the infant visual cortex. Instead, the interocular decorrelations of cortical inputs by experiencing chronic monocular defocus shortly after birth actively disrupts the normal maturation of cortical circuitry in V2.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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