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Kareem Sioufi, Anthony Obeid, Vlad Bekerman, Sandor R. Ferenczy, Jason Hsu, Carol L Shields; Quantification of Optical Coherence Tomography Angiography Metrics and their Relationship to Visual Acuity in Eyes Treated with Plaque Radiotherapy for Uveal Melanoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5972.
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© ARVO (1962-2015); The Authors (2016-present)
To quantify optical coherence tomography angiography (OCTA) metrics in eyes treated with plaque radiotherapy for uveal melanoma.
Retrospective review of 117 eyes treated with plaque radiotherapy and scanned using Optovue RTVue XR Avanti (Optovue, Fremont CA, USA). Eyes with subretinal fluid and/or cystoid macular edema affecting segmentation boundaries were excluded from the analysis. OCTA metrics including foveal avascular zone area (FAZ, mm2), capillary density (CD, %), and perfusion area (PA, mm2) were obtained at the superficial (sFAZ, sCD, sPA) and the deep (dFAZ, dCD, dPA) plexuses using the native AngioAnalytics software (version 2016.1.0.26) available on Optovue. Correlation between OCTA metrics and LogMAR visual acuity (VA) at time of OCTA acquisition was conducted. All statistical analyses were performed with SPSS, Version 24 (SPSS, Inc, Chicago, Illinois, USA).
There were 61 eyes included in the study. Mean patient age was 54 years, and there were 34 females (56%). Mean interval between plaque application and OCTA acquisition was 35 months (median: 21, 4.1-158 months). There was no statistically significant correlation between LogMAR VA and sFAZ, dFAZ, sCD, and dCD (all p≥0.110). In contrast, there was a statistically significant negative correlation between LogMAR VA and sPA (ρ=0.365, p<0.01) and dPA (ρ=0.281, p=0.039).
Analysis of OCTA metrics showed that vascular perfusion area at the superficial plexus had the strongest correlation with visual acuity.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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