July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Quantification of Optical Coherence Tomography Angiography Metrics and their Relationship to Visual Acuity in Eyes Treated with Plaque Radiotherapy for Uveal Melanoma
Author Affiliations & Notes
  • Kareem Sioufi
    Philadelphia, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Anthony Obeid
    Philadelphia, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Vlad Bekerman
    Philadelphia, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Sandor R. Ferenczy
    Philadelphia, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Jason Hsu
    Philadelphia, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Carol L Shields
    Philadelphia, Wills Eye Hospital, Philadelphia, Pennsylvania, United States
  • Footnotes
    Commercial Relationships   Kareem Sioufi, None; Anthony Obeid, None; Vlad Bekerman, None; Sandor Ferenczy, None; Jason Hsu, Optovue (C); Carol Shields, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5972. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Kareem Sioufi, Anthony Obeid, Vlad Bekerman, Sandor R. Ferenczy, Jason Hsu, Carol L Shields; Quantification of Optical Coherence Tomography Angiography Metrics and their Relationship to Visual Acuity in Eyes Treated with Plaque Radiotherapy for Uveal Melanoma. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5972.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : To quantify optical coherence tomography angiography (OCTA) metrics in eyes treated with plaque radiotherapy for uveal melanoma.

Methods : Retrospective review of 117 eyes treated with plaque radiotherapy and scanned using Optovue RTVue XR Avanti (Optovue, Fremont CA, USA). Eyes with subretinal fluid and/or cystoid macular edema affecting segmentation boundaries were excluded from the analysis. OCTA metrics including foveal avascular zone area (FAZ, mm2), capillary density (CD, %), and perfusion area (PA, mm2) were obtained at the superficial (sFAZ, sCD, sPA) and the deep (dFAZ, dCD, dPA) plexuses using the native AngioAnalytics software (version 2016.1.0.26) available on Optovue. Correlation between OCTA metrics and LogMAR visual acuity (VA) at time of OCTA acquisition was conducted. All statistical analyses were performed with SPSS, Version 24 (SPSS, Inc, Chicago, Illinois, USA).

Results : There were 61 eyes included in the study. Mean patient age was 54 years, and there were 34 females (56%). Mean interval between plaque application and OCTA acquisition was 35 months (median: 21, 4.1-158 months). There was no statistically significant correlation between LogMAR VA and sFAZ, dFAZ, sCD, and dCD (all p≥0.110). In contrast, there was a statistically significant negative correlation between LogMAR VA and sPA (ρ=0.365, p<0.01) and dPA (ρ=0.281, p=0.039).

Conclusions : Analysis of OCTA metrics showed that vascular perfusion area at the superficial plexus had the strongest correlation with visual acuity.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×