July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Retinal lipid and glucose metabolism dictates angiogenesis
Author Affiliations & Notes
  • Jean-Sebastien Joyal
    Pediatrics and Pharmacology, University of Montreal, Montreal, Quebec, Canada
  • Footnotes
    Commercial Relationships   Jean-Sebastien Joyal, None
  • Footnotes
    Support  NIH grants: EY024864, EY017017, P01 HD18655
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5995. doi:
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      Jean-Sebastien Joyal; Retinal lipid and glucose metabolism dictates angiogenesis. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5995.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : Tissues with high metabolic rates often use lipid as well as glucose for energy, conferring a survival advantage during feast and famine. Current dogma suggests that high-energy consuming photoreceptors depend on glucose. However, we found that retina also uses fatty acid β-oxidation for energy. Lipid sensors curb glucose uptake when fatty acids are available. Impaired glucose entry into photoreceptors results in a dual lipid/glucose fuel shortage and reduction in the Krebs cycle intermediate α-ketoglutarate (KG) to promote hypoxia- induced factor-1α stabilization and vascular endothelial growth factor secretion, attracting neovessels to supply fuel. Dysregulated lipid and glucose photoreceptor energy metabolism may therefore be a driving force in neovascular retinal diseases.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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