July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Protein synthesis and lipid metabolism as key pathogenic processes of retinal sensibility to diabetes
Author Affiliations & Notes
  • Patrice E Fort
    Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, United States
    Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States
  • Footnotes
    Commercial Relationships   Patrice Fort, None
  • Footnotes
    Support  EY20582, EY020895, DK094292, F043757, ADA 1-04-RA-31; P30 EY007003
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 5997. doi:
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      Patrice E Fort; Protein synthesis and lipid metabolism as key pathogenic processes of retinal sensibility to diabetes. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5997.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Presentation Description : Diabetes is a catabolic disorder with dramatic impact on multiple tissues. While the retina is not an exception, we showed that its metabolism and its regulation is unique in the way it is regulated. This presentation will focus on the specific regulation of protein synthesis by Akt/mTOR signaling in the retinal tissue and the relative contribution and specific regulation of TORC1 and TORC2. This presentation will additionally report how diabetes also affects another aspect of tissue integrity: lipid metabolism. A combination of transcriptomic and lipidomic analyses were used to assess the impact of diabetes on human retinal lipid metabolism and revealed its link to DR development.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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