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Patrice E Fort; Protein synthesis and lipid metabolism as key pathogenic processes of retinal sensibility to diabetes. Invest. Ophthalmol. Vis. Sci. 2018;59(9):5997.
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Presentation Description :
Diabetes is a catabolic disorder with dramatic impact on multiple tissues. While the retina is not an exception, we showed that its metabolism and its regulation is unique in the way it is regulated. This presentation will focus on the specific regulation of protein synthesis by Akt/mTOR signaling in the retinal tissue and the relative contribution and specific regulation of TORC1 and TORC2. This presentation will additionally report how diabetes also affects another aspect of tissue integrity: lipid metabolism. A combination of transcriptomic and lipidomic analyses were used to assess the impact of diabetes on human retinal lipid metabolism and revealed its link to DR development.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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