July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Electron-beam irradiated corneal (haloTM) versus scleral patch graft erosion rates in glaucoma drainage device surgery
Author Affiliations & Notes
  • Ross Passo
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Zachary Hoskins
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Khoa D. Tran
    Research and Development, Lions VisionGift, Portland, Oregon, United States
  • Corrina Patzer
    Research and Development, Lions VisionGift, Portland, Oregon, United States
  • Shandiz Tehrani
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States
  • Footnotes
    Commercial Relationships   Ross Passo, None; Zachary Hoskins, None; Khoa Tran, Lions VisionGift (F); Corrina Patzer, Lions VisionGift (F); Shandiz Tehrani, None
  • Footnotes
    Support  NIH/NEI P30 EY010572 (OHSU), an unrestricted grant from Research to Prevent Blindness (OHSU)
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 6085. doi:
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      Ross Passo, Zachary Hoskins, Khoa D. Tran, Corrina Patzer, Shandiz Tehrani; Electron-beam irradiated corneal (haloTM) versus scleral patch graft erosion rates in glaucoma drainage device surgery. Invest. Ophthalmol. Vis. Sci. 2018;59(9):6085.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : Patch graft erosion and implant exposure is a known complication of glaucoma drainage device (GDD) surgery. Recently, electron-beam (e-beam) irradiated corneal grafts (haloTM) have become available. Limited data exist on the rates of erosion for haloTM corneal grafts compared to traditional scleral grafts after GDD surgery. This retrospective study examines the rate of haloTM corneal graft versus scleral graft erosion in adult GDD surgery at a single academic institution.

Methods : Records of 258 adult subjects (age > 18) who underwent GDD surgery at the Casey Eye Institute by 5 surgeons between April 22, 2014 and October 11, 2017 were retrospectively reviewed. The occurrence of graft erosion in these patients post GDD surgery was determined using billing codes and verified by reviewing operative reports. Statistical analysis was performed using Fishers exact, Wilcoxon, and t tests where appropriate.

Results : Of 258 patients, 204 (79.1%) received haloTM corneal grafts and 54 (20.9%) received scleral grafts. Diagnoses at the time of GDD surgery included primary open-angle glaucoma (35.7%), secondary glaucoma (28.7%), uveitic glaucoma (17.1%), neovascular glaucoma (8.1%), angle closure glaucoma (6.2%), ocular hypertension (3.9%), and other (0.4%). The average age at the time of GDD surgery was 61.1 ± 17.5 years and 60.4 ± 16.7 years for the haloTM and sclera groups, respectively. Mean follow up time post GDD surgery was 417 ± 345 days and 400 ± 345 days for the haloTM and sclera groups, respectively. No cases of graft erosion in either group was noted during the follow up period. There were no statistically significant differences in sex, age, follow up time, and glaucoma diagnosis between the haloTM and sclera groups.

Conclusions : While e-beam irradiated haloTM corneal grafts were used more frequently relative to scleral grafts in GDD surgery, no increase in the rate of graft erosion was noted relative to scleral grafts during the follow up period.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

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