July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
OCT analysis of Bruch’s opening-minimum rim width and cup depth in eyes with compressive chiasmal lesions. Correlation with peripapillary retinal nerve fiber layer and standard automated perimetry.
Author Affiliations & Notes
  • Rafael Barbosa de Araujo
    Ophthalmology, Faculdade de Med da Univ de Sao Paulo, S?o Paulo, S?o Paulo, Brazil
  • Leandro C Zacharias
    Ophthalmology, Faculdade de Med da Univ de Sao Paulo, S?o Paulo, S?o Paulo, Brazil
  • Maria Kiyoko Oyamada
    Ophthalmology, Faculdade de Med da Univ de Sao Paulo, S?o Paulo, S?o Paulo, Brazil
  • Rony Carlos Preti
    Ophthalmology, Faculdade de Med da Univ de Sao Paulo, S?o Paulo, S?o Paulo, Brazil
  • Mario L R Monteiro
    Ophthalmology, Faculdade de Med da Univ de Sao Paulo, S?o Paulo, S?o Paulo, Brazil
  • Footnotes
    Commercial Relationships   Rafael Barbosa de Araujo, None; Leandro Zacharias, None; Maria Oyamada, None; Rony Preti, None; Mario Monteiro, None
  • Footnotes
    Support  Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, Grant No 2013/26585-5)
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1125. doi:
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      Rafael Barbosa de Araujo, Leandro C Zacharias, Maria Kiyoko Oyamada, Rony Carlos Preti, Mario L R Monteiro; OCT analysis of Bruch’s opening-minimum rim width and cup depth in eyes with compressive chiasmal lesions. Correlation with peripapillary retinal nerve fiber layer and standard automated perimetry.. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1125.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : To measure Bruch’s membrane opening-minimum rim width (BMO-MRW) and cup depth using optical coherence tomography (OCT) in eyes with compressive chiasmal lesions and band atrophy (BA) of the optic nerve. To compare the ability of BMO-MRW and retinal nerve fiber layer (RNFL) thickness measurements to detect structural abnormalities in such eyes.

Methods : We performed a cross-sectional, prospective study, with 49 eyes with BA and bitemporal hemianopia caused by optic chiasm compression and 39 eyes of normal age-matched controls. BMO-MRW and RNFL measurements with OCT and visual field (VF) testing were acquired and analyzed between both groups. BMO-MRW was measured with disc centered radial OCT scans as the shortest distance between the Bruch’s membrane terminations to the internal limiting membrane. Cup depth was measured from the line connecting Bruch’s membrane termination to the bottom of the cup. BMO-MRW and RNFL parameters in BA eyes and controls were compared. The area under the receiver operating characteristic (AUC) curves was calculated and compared for global and sectoral optic disc parameters. Correlation between VF and BMO-MRW parameters were assessed.

Results : BMO-MRW measurements were generally reduced in eyes with BA compared to controls. The highest reduction rates were found in the nasal, temporal and horizontal values, with strong correlation with VF parameters. AUCs were significantly greater for RNFL thickness parameters than BMO-MRW in the global, temporal, nasal, inferonasal and horizontal measurements. No significant difference was found in cup depth measurements between BA and healthy eyes.

Conclusions : BMO-MRW reduction occurs in all optic disc sectors but is greater in the nasal and temporal quadrants and correlates with peripapillary RNFL and VF loss in eyes with BA of the optic nerve while depth does not differ from controls. BMO-MRW and RNFL are useful parameters in evaluating BA of the optic nerve and addressing the cup depth may be useful to differentiate from glaucomatous cupping.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Infrared image of a study participant illustrating the 24 radial B-scans centered on the optic nerve head and the orientation of the axis connecting the fovea to the Bruch’s membrane opening center.

Infrared image of a study participant illustrating the 24 radial B-scans centered on the optic nerve head and the orientation of the axis connecting the fovea to the Bruch’s membrane opening center.

 

Box plot analysis of BMO-MRW from BA patients and healthy eyes.

Box plot analysis of BMO-MRW from BA patients and healthy eyes.

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