July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Segmentation and characterization of intra-retina layer thickness in widefield SS-OCT: comparison of normal retina and diabetic retinopathy with/without macular edema
Author Affiliations & Notes
  • Luis De Sisternes
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Homayoun Bagherinia
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Thomas Perez
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Thomas Callan
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Mary K Durbin
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Scott S Lee
    East Bay Retina Consultants, Inc., Oakland, California, United States
  • Jesse J Jung
    East Bay Retina Consultants, Inc., Oakland, California, United States
  • Footnotes
    Commercial Relationships   Luis De Sisternes, Carl Zeiss Meditec, Inc. (E); Homayoun Bagherinia, Carl Zeiss Meditec, Inc. (E); Thomas Perez, Carl Zeiss Meditec, Inc. (C); Thomas Callan, Carl Zeiss Meditec, Inc. (E); Mary Durbin, Carl Zeiss Meditec, Inc. (E); Scott Lee, Carl Zeiss Meditec, Inc. (C); Jesse Jung, Carl Zeiss Meditec, Inc. (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1512. doi:
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      Luis De Sisternes, Homayoun Bagherinia, Thomas Perez, Thomas Callan, Mary K Durbin, Scott S Lee, Jesse J Jung; Segmentation and characterization of intra-retina layer thickness in widefield SS-OCT: comparison of normal retina and diabetic retinopathy with/without macular edema. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1512.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : While advances in Optical Coherence Tomography (OCT) technology allow for the collection of widefield volumes, little is known about peripheral intra-retinal layer thickness in diseased eyes. We investigate thickness differences within the central macula and periphery between healthy and diabetic retinopathy eyes without (DR) and with macular edema (DME) using a novel tool to outline intra-retina layer boundaries in widefield OCT volumes.

Methods : Retinal OCT Angiography volumes of 15x9mm field of view were collected from healthy, DR and DME eyes using a Swept Source OCT device (PLEX® Elite 9000; ZEISS, Dublin, CA). We developed an automated tool to outline 10 intra-retinal boundaries in widefield OCT volumes. We quantified inner and outer retina thickness (separated by the inner border of the outer plexiform layer) in the standard 9 ETDRS sectors (within 3mm from the fovea) and in a proposed peripheral grid with 16 additional sectors (up to 7.5mm from the fovea, Figure 1A). Statistical significance of the differences between healthy and diseased eyes was evaluated using t-test and corrected by a multiple hypothesis testing scenario (q-value). Intra-layer thickness differences were also evaluated in topographic maps across the 15x9mm field of view.

Results : Figure 1C provides a summary of sectors and values of statistically significant (q<0.05) thickness differences of diseased eyes compared to healthy eyes. For DR eyes (N=22), thinning was observed for 1 inner retina and 3 outer retina ETDRS sectors compared with normal eyes (N=39). In contrast, thickening was observed for 5 inner retina peripheral sectors. For DME eyes (N=12), thickening was observed for 7 inner retina and 9 outer retina ETDRS sectors, and in 11 inner retina and 8 outer retina peripheral sectors. Topographic thickness maps provided a clear visualization of localized regions of thinning or thickening for disease cases in the central macula as well as in the periphery.

Conclusions : Our results suggest significant differences in intra-retinal layer thickness between healthy and disease eyes in regions both in the central macula and peripheral retina. DME eyes are also more likely to have retinal edema in the peripheral retina.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Figure 1: A) Example of DR thickness map with sector locations. B) B-scan with segmentation lines. C) Summary of sector differences.

Figure 1: A) Example of DR thickness map with sector locations. B) B-scan with segmentation lines. C) Summary of sector differences.

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