July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
The effect of Ultrasound cycloplasty (UCP) using High Intensity Focused Ultrasound (HiFU) on aqueous humor dynamics
Author Affiliations & Notes
  • Pouya Alaghband
    Ophthalmology, St. Thomas' Hospital, London, United Kingdom
    King's College London, London, United Kingdom
  • Elizabeth Angela P Galvis
    Ophthalmology, St. Thomas' Hospital, London, United Kingdom
  • Michael Madekurozwa
    Imperial College London, London, United Kingdom
  • Esmail Eslah
    Eye, Al-Bahar, Kuwait, Kuwait
  • Brian Chu
    Oxford University, Oxford, United Kingdom
  • Darryl R Overby
    Imperial College London, London, United Kingdom
  • K Sheng Lim
    Ophthalmology, St. Thomas' Hospital, London, United Kingdom
    King's College London, London, United Kingdom
  • Footnotes
    Commercial Relationships   Pouya Alaghband, None; Elizabeth Galvis, None; Michael Madekurozwa, None; Esmail Eslah, None; Brian Chu, None; Darryl Overby, None; K Sheng Lim, None
  • Footnotes
    Support  none
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 1648. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Pouya Alaghband, Elizabeth Angela P Galvis, Michael Madekurozwa, Esmail Eslah, Brian Chu, Darryl R Overby, K Sheng Lim; The effect of Ultrasound cycloplasty (UCP) using High Intensity Focused Ultrasound (HiFU) on aqueous humor dynamics. Invest. Ophthalmol. Vis. Sci. 2018;59(9):1648.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Ultrasound cycloplasty (UCP) is a new procedure utilising High Intensity Focused Ultrasound (HIFU) for treating glaucoma. This study explores the effect of UCP on aqueous humor dynamics in patients with glaucoma.

Methods : All subjects attending the glaucoma clinic who had uncontrolled intraocular pressure (IOP) for treated primary open angle glaucoma (POAG) were offered UCP procedure. All UCP procedures were performed under peri-bulbar anaesthesia. Post-operatively, patients were treated topically with steroids for four weeks.
All glaucoma treatments were stopped, one month before the baseline and 3 months’ post-operative aqueous dynamic measurements.
Inclusion Criteria
All adult patients with uncontrolled POAG.
Exclusion Criteria
Previous intraocular surgery, except SLT/ALT laser
Other types of glaucoma
Use of systemic medication such as beta-blockers
A history of allergy to fluorescein
Outcome Measures
Intraocular pressure (Goldmann tonometry)
Facility of outflow (Schiøtz tonography)
Rate of aqueous flow (fluorophotometry)
Uveoscleral outflow (calculated from Goldmann’s equation)

Results : 32 patients were recruited into the study. One patient had very high IOP after 2 weeks’ washout and another patient had normal IOP after washout were withdrawn from the study.
Uveoscleral outflow was calculated using Goldmann’s equation with an assumed episcleral venous pressure of 10 mmHg.
Ft = C (IOP – Pv) + Fu
Therefore: Fu = Ft – C (IOP – Pv)
Fu= Uveoscleral outflow
Ft = rate of aqueous humor formation
C = tonographic facility of outflow
IOP = intraocular pressure
Pv = episcleral venous pressure

Table 1. Aqueous humor parameters comparison before and after HiFU treatment

Conclusions : This is the first study investigating aqueous humor dynamics after application of UCP in patients with uncontrolled POAG. We demonstrated that UCP reduced IOP 3-months postoperatively effectively by 14% whilst aqueous flow decreased by 11.3%. Moreover, tonographic outflow facility and calculated uveoscleral outflow remained unchanged.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×