July 2018
Volume 59, Issue 9
Free
ARVO Annual Meeting Abstract  |   July 2018
Comparison of retinal ganglion cell indices determined from different SITA threshold strategies
Author Affiliations & Notes
  • Sophia Yu
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Gary C Lee
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Thomas Callan
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Buck Cunningham
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Mary K Durbin
    Carl Zeiss Meditec, Inc., Dublin, California, United States
  • Anders Heijl
    Lund University, Malmo, Sweden
  • Aiko Iwase
    Tajimi Iwase Eye Clinic, Tajimi, Japan
  • Luke Xiang-Yu Chong
    University of California- Berkeley, Berkeley, California, United States
  • John G Flanagan
    University of California- Berkeley, Berkeley, California, United States
  • Chris Leung
    The Chinese University of Hong Kong, Shatin, Hong Kong
  • Boel Bengtsson
    Lund University, Malmo, Sweden
  • Footnotes
    Commercial Relationships   Sophia Yu, Carl Zeiss Meditec, Inc. (E); Gary Lee, Carl Zeiss Meditec, Inc. (E); Thomas Callan, Carl Zeiss Meditec, Inc. (E); Buck Cunningham, Carl Zeiss Meditec, Inc. (E); Mary Durbin, Carl Zeiss Meditec, Inc. (E); Anders Heijl, Carl Zeiss Meditec, Inc. (C), Carl Zeiss Meditec, Inc. (F); Aiko Iwase, Carl Zeiss Meditec, Inc. (F), Carl Zeiss Meditec, Inc. (R); Luke Chong, Carl Zeiss Meditec, Inc. (F); John Flanagan, Carl Zeiss Meditec, Inc. (F), Carl Zeiss Meditec, Inc. (C); Chris Leung, Carl Zeiss Meditec, Inc. (F), Carl Zeiss Meditec, Inc. (P), Carl Zeiss Meditec, Inc. (R); Boel Bengtsson, Carl Zeiss Meditec, Inc. (C)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2124. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Sophia Yu, Gary C Lee, Thomas Callan, Buck Cunningham, Mary K Durbin, Anders Heijl, Aiko Iwase, Luke Xiang-Yu Chong, John G Flanagan, Chris Leung, Boel Bengtsson; Comparison of retinal ganglion cell indices determined from different SITA threshold strategies. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2124.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose : Glaucomatous disease, ultimately related to the loss of retinal ganglion cells (RGC), is most commonly assessed from the structural changes detected by optical coherence tomography (OCT) and functional changes detected by standard automated perimetry. Medeiros et al. (AJO. 2012; 154:814-824) proposed a structure-function RGC index (RGCI) using SITA Standard (SS) visual fields (VF), giving a combined model to monitor glaucoma's progression, as compared to isolated structural or functional metrics. We investigated differences in the RGCI when estimated from 3 types of SITA VFs in glaucomatous eyes.

Methods : 24-2 SS, SITA Fast (SF), and SITA Faster (SFR) VF and spectral domain OCT were acquired from 100 eyes of 100 glaucoma patients at 2 repeat visits within 1 month, using HFA3 (ZEISS, Dublin, CA) and CIRRUS™ HD-OCT (ZEISS, Dublin, CA). Using Medeiros’ previously described method, RGCIs were calculated using the 3 SITA VFs and the same OCT data between visits. Significance testing (2 one-sided, paired t-tests, ∝ = 0.05) for inter-strategy equivalence versus RGCISS was performed with Visit 2 data, using limits of equivalence of ± 5% from the reference RGCISS mean. Intra-strategy equivalence for RGCISS was similarly tested using data from both visits. Test-retest standard deviation (TRT-SD) and coefficient of variation (CV) were calculated for repeatability.

Results : Mean age was 67.1 ± 10.9 years (range: 26.9 to 82.7 years). Table 1 shows the mean ± SD for the OCT average retinal nerve fiber (RNFL) thickness, VF Mean Deviations (MD), and RGCIs. Bland-Altman and scatter plots (Fig. 1) show good agreements and strong correlations (comparable limits of agreement with Pearson’s r> 0.98) for all comparisons. RGCISF and RGCISFR were statistically equivalent to RGCISS (P < 0.001 and P < 0.001, respectively). TRT-SD and CV of RGCISF and RGCISFR were no worse than the values for RGCISS, indicating comparable variabilities, which were also larger in magnitude than inter-strategy differences.

Conclusions : RGCIs calculated from OCT and the various types of SITA VFs produced comparable values in a wide range of glaucomatous eyes and, therefore, could be compatible in mixed analyses. TRT variabilities were comparable among all index versions.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.

 

Table 1. Mean ± SD of Summary Parameters & Repeatability Metrics

Table 1. Mean ± SD of Summary Parameters & Repeatability Metrics

 

Figure 1. Intra-Strategy (Top) & Inter-Strategy (Middle, Bottom) Scatter & Bland-Altman comparisons of RGCIs

Figure 1. Intra-Strategy (Top) & Inter-Strategy (Middle, Bottom) Scatter & Bland-Altman comparisons of RGCIs

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×