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Anna G Mackin, Jennifer L Jung, Jennifer L. Patnaik, Brandie D Wagner, Erica Wymore, Jennifer Hodges, Jasleen K Singh, Emily A McCourt, Cathcart N Jennifer, Alan G Palestine, Anne M Lynch; Risk of Retinopathy of Prematurity Across Fenton Chart Birth Weight Percentiles. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2756. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the association between birth weight percentile on the Fenton preterm growth chart and the risk for developing retinopathy of prematurity (ROP).
Retrospective review of 1294 infants (January 2006 - April 2016) was performed using a ROP registry. We examined the birth weight percentile using the Fenton preterm growth chart. Weight percentile groups were categorized as follows: ≤3rd (group 1), 4-10th (group 2), 11-24th (group 3), 25-75th (group 4), >75th (group 5). The incidence of severe ROP (defined as ETROP types 1 and 2) and low grade ROP was compared across the percentile groups using univariate logistic regression to compare severe and low grade ROP to no ROP.
Of 1294 infants, 130 (10.0%) had severe ROP, 270 (20.9%) had low grade ROP, and 894 (69.1%) had no ROP. Among infants with severe ROP, 14 (10.8%), 13 (10.0%), 15 (11.5%), 71 (54.6%) and 17 (13.1%) were in groups 1, 2, 3, 4, 5 respectively based on birth weight percentile. Among infants with low grade ROP, 10 (3.7%), 19 (7.0%), 37 (13.7%), 167 (61.8%) and 37 (13.7%) were in groups 1, 2, 3, 4, 5 respectively based on birth weight percentile. As demonstrated in the Table, infants in group 1 had significantly higher odds of severe ROP (Odds Ratio [OR] 2.14, 95% Confidence Interval [CI] 1.12-4.09, p = 0.0088) but not of low grade ROP (OR 0.65, 95% CI 0.32-1.32, p = 0.5785) as compared to group 4.
Infants born at the lower extreme of the Fenton birth weight percentile are at significantly higher odds of developing type 1 or type 2 ROP.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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