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chiaki nogawa, Tsuneaki Handa, kotaro tsuboi, Motohiro Kamei; Morphological changes of iris neovascularization evaluated with anterior OCT angiography. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2823. doi: https://doi.org/.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the morphological changes of iris neovascularizations (NVIs) in eyes with ischemic retinal disorders with treatment using anterior optical coherence tomography angiography (a-OCTA).
Twelve consecutive eyes with ischemic retinal disorders (i.e. proliferative diabetic retinopathy, central retinal vein occlusion and ocular ischemic syndrome) were examined with a-OCTA, slit lamp and gonioscopy. A-OCTA images were acquired using RTVue XR Avanti® (Optovue) with the ”cornea and anterior module lens”. Morphologies of the NVIs were assessed before and after the treatments.
In 7 of 12 eyes, NVIs were detected with the a-OCTA before the treatment. In those 7 eyes, the slit lamp examination revealed the NVIs in 5 eyes and the gonioscopic examination detected neovascularization in the angle in 2 eyes. No NVI was detected by slit lamp or gonioscopic examinations in the 5 eyes which showed no NVI with the a-OCTA. The a-OCTA detected an increase of the NVI before intervention in an eye with CRVO. All 7 eyes with the NVIs before treatment showed regression or complete disappearance of the NVIs after the treatments regardless of the methods including anti-VEGF therapy, pan-retinal laser photocoagulation, vitrectomy, and pressure-lowering eye drops. Interestingly, the regression in morphology from exuberant to simple shape correlated with a decrease of the intraocular pressure (IOP) with treatments in 3 eyes with elevated IOP.
The a-OCTA clearly and easily visualized NVIs. The morphology of NVI might represent its activity and evaluating morphological change with a-OCTA can be a useful indicator for treatments.
This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.
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