July 2018
Volume 59, Issue 9
Open Access
ARVO Annual Meeting Abstract  |   July 2018
Morphological changes of iris neovascularization evaluated with anterior OCT angiography
Author Affiliations & Notes
  • chiaki nogawa
    Aichi Medical Univercity, Nagakute, Aichi, Japan
  • Tsuneaki Handa
    Aichi Medical Univercity, Nagakute, Aichi, Japan
  • kotaro tsuboi
    Aichi Medical Univercity, Nagakute, Aichi, Japan
  • Motohiro Kamei
    Aichi Medical Univercity, Nagakute, Aichi, Japan
  • Footnotes
    Commercial Relationships   chiaki nogawa, None; Tsuneaki Handa, None; kotaro tsuboi, None; Motohiro Kamei, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science July 2018, Vol.59, 2823. doi:
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      chiaki nogawa, Tsuneaki Handa, kotaro tsuboi, Motohiro Kamei; Morphological changes of iris neovascularization evaluated with anterior OCT angiography. Invest. Ophthalmol. Vis. Sci. 2018;59(9):2823.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose : To evaluate the morphological changes of iris neovascularizations (NVIs) in eyes with ischemic retinal disorders with treatment using anterior optical coherence tomography angiography (a-OCTA).

Methods : Twelve consecutive eyes with ischemic retinal disorders (i.e. proliferative diabetic retinopathy, central retinal vein occlusion and ocular ischemic syndrome) were examined with a-OCTA, slit lamp and gonioscopy. A-OCTA images were acquired using RTVue XR Avanti® (Optovue) with the ”cornea and anterior module lens”. Morphologies of the NVIs were assessed before and after the treatments.

Results : In 7 of 12 eyes, NVIs were detected with the a-OCTA before the treatment. In those 7 eyes, the slit lamp examination revealed the NVIs in 5 eyes and the gonioscopic examination detected neovascularization in the angle in 2 eyes. No NVI was detected by slit lamp or gonioscopic examinations in the 5 eyes which showed no NVI with the a-OCTA. The a-OCTA detected an increase of the NVI before intervention in an eye with CRVO. All 7 eyes with the NVIs before treatment showed regression or complete disappearance of the NVIs after the treatments regardless of the methods including anti-VEGF therapy, pan-retinal laser photocoagulation, vitrectomy, and pressure-lowering eye drops. Interestingly, the regression in morphology from exuberant to simple shape correlated with a decrease of the intraocular pressure (IOP) with treatments in 3 eyes with elevated IOP.

Conclusions : The a-OCTA clearly and easily visualized NVIs. The morphology of NVI might represent its activity and evaluating morphological change with a-OCTA can be a useful indicator for treatments.

This is an abstract that was submitted for the 2018 ARVO Annual Meeting, held in Honolulu, Hawaii, April 29 - May 3, 2018.



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